[Evaluation of biogeochemical factors influence on the prevalence of urolithiasis in the regions of Tajikistan].

The investigation has been undertaken to study a relationship between some biogeochemical and environmental factors and nephrolithiasis morbidity in the regions of Tajikistan. The paper presents the data of a comprehensive study comprising the biochemical, chromatographic, and mass-spectrometric studies of 1180 patients aged 14 to 76 years, treated at the Dushanbe Urology Medical Center. The performed examination has established a relationship of the higher urolithiasis mortality rates in the poor environmental regions of the Republic of Tajikistan to the high pollution by organic and inorganic substances, the high natural mineralization and hardness of water, the high levels of chlorides, sulfates, and other components of salt composition, which in turn affects the course of a pathological process.

[Chromatographic mass spectrometric assessment of the course of different forms of urolithiasis].

The study has been undertaken to improve the methods for diagnosing urolithiasis, which comprehensively evaluate the severity of a pathological process and the results of treatment in patients with nephrolithiasis. The paper gives the data of investigating the processes of chromatographic mass spectrometric urinalysis in 82 patients aged 15 to 81 years urgently admitted to the units of urology of Moscow City Clinical Hospital Seven for a renal colic attack. The levels of lithogenic substances were measured in patients with different types of metabolic disturbances. There was evidence that the chromatographic mass spectrometric parameters of the level of lithogenic substances and hydrolytic enzymes might be used as diagnostic criteria for the progression of urolithiasis, the prediction of the severity of a pathological process, and the development of preventive methods against lithogenesis in patients with a renal colic attack.

[Urolithiasis morbidity in Tadzhikistan regions: some biogeochemical and environmental factors].

The aim of the study was to investigate urolithiasis prevalence in the main administrative regions of Tadzhikistan, to ascertain effects of drinking water quality, water pollutants and other environmental factors on urolithiasis morbidity in endemic regions of Tadzhikistan. It was found that high urolithiasis incidence rate in some regions was associated with high water pollution (class III and IV), its high natural mineralization and hardness, high content of chlorides, sulphates and other components of salt composition, organic and non-organic pollutants. Chemical and microbiological tests showed that sanitary standards were not strictly observed in the regions with high urolithiasis morbidity. These regions are also characterized by high incidence of acute intestinal infections, thyphoid, nephropathies, high environmental pollution, high density of population.

[Potentialities of current methods for laboratory analysis in the evaluation of the severity and prevalence of nephrolithiasis in Tajikistan].

The investigation was undertaken to study a relationship between some biogeochemical and environmental factors and nephrolithiasis morbidity rates in the regions of Tajikistan. The paper presents the data of an integrated examination involving biochemical, chromatographic, and mass-spectrometric studies of 1180 patients aged 14 to 76 years who have been treated at the Dushanbe Urology Medical Center. The investigation established a relationship of an increase in ICD morbidity in poor environmental regions of the Republic of Tajikistan to the high organic and non-organic pollution, the high natural mineralization and hardness of water, and the elevated levels of chlorides, sulfates, and other salt components, which in turn influences the severity of a pathological process.