Patient specific quality assurance of volumetric modulated arc therapy of synchronous bilateral breast cancer.

Synchronous bilateral breast cancers (SBBC) present a considerable issue in external beam radiotherapy because of large fields size and large target volumes. Mono-isocentric volumetric modulated arc therapy (VMAT) appears as an appropriate irradiation technique for these types of tumors. The aim of this study was to demonstrate the utility of a 3D DVH pretreatment quality assurance program in VMAT of SBBC cases. Twenty SBBC patients who underwent radiation therapy in our department were retrospectively enrolled in this study. Fifteen patients were treated exclusively to the mammary glands. Five patients benefited from a dose boost on the tumor bed (60Gy). Nine patients were irradiated on the supraclavicular nodes (50Gy). This dose was delivered in 25 fractions and integrated boost was used when appropriate. Depending on the complexity of the treatment plans; 2 or 4 arcs VMAT plans were used in a mono-isocentric technique. The patient specific quality assurance (PSQA) was evaluated using COMPASS measured data, COMPASS reconstructed (CR) and COMPASS computed (CC) dose compared to treatment planning system (TPS) dose. Clinical evaluation was based on DVH metrics for target volumes and organ at risks. The maximum average dose deviation between TPS, CC, and CR was below 3%. The paired t-test between TPS, CC, and CR shows a strong agreement (p < 0.001). The 3DVH dose distribution comparison between TPS and COMPASS were also performed with good gamma score for global analysis. COMPASS was successfully evaluated as a 3DVH pretreatment system for SBBC despite the large fields size and complex target volumes. It allows the verification of the plan in 3D patient anatomy and the evaluation of dose discrepancies.

VMAT partial arc technique decreases dose to organs at risk in whole pelvic radiotherapy for prostate cancer when compared to full arc VMAT and IMRT.

Whole pelvic radiotherapy (WPRT) can sterilize microscopic lymph node metastases in treatment of prostate cancer. WPRT, compared to prostate only radiotherapy (PORT), is associated with increased acute gastrointestinal, and hematological toxicities. To further explore minimizing normal tissue toxicities associated with WPRT in definitive IMRT for prostate cancer, this planning study compared dosimetric differences between static 9-field-IMRT, full arc VMAT, and mixed partial-full arc VMAT techniques. In this retrospective study, 12 prostate cancer patients who met the criteria for WPRT were randomly selected for this study. The initial volume, PTV46, included the prostate, seminal vesicles, and pelvic nodes with margin and was prescribed to 4600 cGy. The cone-down volume, PTV78, included the prostate and proximal seminal vesicles with margin to a total dose of 7800 cGy. For each CT image set, 3 plans were generated for each of the PTVs: an IMRT plan, a full arc (FA) VMAT plan, and a mixed partial-full arc (PFA) VMAT plan, using 6MV photons energy. According to RTOG protocols none of the plans had a major Conformity Index (CI) violation by any of the 3 planning techniques. PFA plan had the best mean CI index of 1.00 and significantly better than IMRT (p = 0.03) and FA (p = 0.007). For equivalent PTV coverage, the average composite gradient index of the PFA plans was better than the IMRT and the FA plans with values 1.92, 2.03, and 2.01 respectively. The defference was statistically significant between PFA/IMRT and PFA/FA, with p- values of < 0.001. The IMRT plans and the PFA plans provided very similar doses to the rectum, bladder, sigmoid colon, and femoral heads, which were lower than the dose in the FA plans. There was a significant decrease in the mean dose to the rectum from 4524 cGy with the FA to 4182 cGy with the PFA and 4091 cGy with IMRT (p < 0.001). The percent of rectum receiving 4000 cGy was also the highest with FA at 66.1% compared to 49.9% (PFA) and 47.5% (IMRT). There was a significant decrease in the mean dose to the bladder from 3922 cGy (FA) to 3551 cGy (PFA) and 3612 cGy (IMRT) (p < 0.001). The percent of bladder receiving 4000 cGy was also the highest with FA at 45.4% compared to 36.6% (PFA) and 37.4% (IMRT). The average mean dose to the sigmoid colon decreased from 4177 cGy (FA) to 3893 cGy (PFA) and 3819 cGy (IMRT). The average mean dose to the femoral heads decreased from 2091 cGy (FA) to 2026 cGy (PFA) and 1987 cGy (IMRT). Considering the improvement in plan quality indices recorded in this study including the dose gradient and the dose to organs at risk, mixed partial-full arc plans may be the preferred VMAT treatment technique over full arc plans for prostate cancer treatments that include nodal volumes.

The Impact of Dose Rate on the Accuracy of Step-and-Shoot Intensity-modulated Radiation Therapy Quality Assurance Using Varian 2300CD.

INTRODUCTION: Intensity-modulated radiation therapy (IMRT) delivery using "step-and-shoot" technique on Varian C-Series linear accelerator (linac) is influenced by the communication frequency between the multileaf collimator and linac controllers. Hence, the dose delivery accuracy is affected by the dose rate. AIM: Our aim was to quantify the impact of using two dose rates on plan quality assurance (QA). MATERIALS AND METHODS: Twenty IMRT patients were selected for this study. The plan QA was measured at two different dose rates. A gamma analysis was performed, and the degree of plan modulation on the QA pass rate was also evaluated in terms of average monitor unit per segment (MU/segment) and the total number of segments. RESULTS: The mean percentage gamma pass rate of 94.9% and 93.5% for 300 MU/min and 600 MU/min dose rate, respectively, was observed. There was a significant (P = 0.001) decrease in percentage gamma pass rate when the dose rate was increased from 300 MU/min to 600 MU/min. There was a weak, but significant association between the percentage pass rate at both dose rate and total number of segments. The total number of MU was significantly correlated to the total number of segments (r = 0.59). We found a positive correlation between the percentage pass rate and mean MU/segment, r = 0.52 and r = 0.57 for 300 MU/min and 600 MU/min, respectively. CONCLUSION: IMRT delivery using step-and-shoot technique on Varian 2300CD is impacted by the dose rate and the total amount of segments.

Enhanced dynamic wedge output factors for Varian 2300CD and the case for a reference database.

Dose inhomogeneity in treatment planning can be compensated using physical wedges. Enhanced dynamic wedges (EDW) were introduced by Varian to overcome some of the shortcomings of physical wedges. The objectives of this study were to measure EDW output factors for 6 MV and 20 MV photon energies for a Varian 2300CD. Secondly, to review the literature in terms of published enhanced dynamic wedge output factors (EDWOF) for different Varian models and thereby add credence to the case of the validity of reference databases. The enhanced dynamic wedge output factors were measured for the Varian 2300CD for both 6MV and 20 MV photon energies. Twelve papers with published EDWOF for different Varian linac models were found in the literature. Comparing our results with the published mean, we found an excellent agreement for 6 MV EDWOF, with the percentage differences ranging from 0.01% to 0.57%, with a mean of 0.03%. The coefficient of variation of published EDWOF ranged from 0.17% to 0.85% and 0.1% to 0.9% for the for 6 MV and 18 MV photon energies, respectively. This paper provides the first published EDWOF for 20 MV photon energy. In addition, we have provided the first compendium of EDWOFs for different Varian linac models. The consistency of value across models and institution provide further support that a standard dataset of basic photon and electron dosimetry could be established as a guide for future commissioning, beam modeling, and quality assurance purposes.

A validation of carbon fiber imaging couch top modeling in two radiation therapy treatment planning systems: Philips Pinnacle3 and BrainLAB iPlan RT Dose.

BACKGROUND: Carbon fiber (CF) is now the material of choice for radiation therapy couch tops. Initial designs included side metal bars for rigidity; however, with the advent of IGRT, involving on board imaging, new thicker CF couch tops without metal bars have been developed. The new design allows for excellent imaging at the expense of potentially unacceptable dose attenuation and perturbation. OBJECTIVES: We set out to model the BrainLAB imaging couch top (ICT) in Philips Pinnacle(3) treatment planning system (TPS), to validate the already modeled ICT in BrainLAB iPlan RT Dose treatment planning system and to compute the magnitude of the loss in skin sparing. RESULTS: Using CF density of 0.55 g/cm(3) and foam density of 0.03 g/cm(3), we demonstrated an excellent agreement between measured dose and Pinnacle(3) TPS computed dose using 6 MV beam. The agreement was within 1% for all gantry angle measured except for 120°, which was 1.8%. The measured and iPlan RT Dose TPS computed dose agreed to within 1% for all gantry angles and field sizes measured except for 100° where the agreement was 1.4% for 10 cm × 10 cm field size. Predicted attenuation through the couch by iPlan RT Dose TPS (3.4% - 9.5%) and Pinnacle(3) TPS (2% - 6.6%) were within the same magnitude and similar to previously reported in the literature. Pinnacle(3) TPS estimated an 8% to 20% increase in skin dose with increase in field size. With the introduction of the CF couch top, it estimated an increase in skin dose by approximately 46 - 90%. The clinical impact of omitting the couch in treatment planning will be dependent on the beam arrangement, the percentage of the beams intersecting the couch and their angles of incidence. CONCLUSION: We have successfully modeled the ICT in Pinnacle(3) TPS and validated the modeled ICT in iPlan RT Dose. It is recommended that the ICT be included in treatment planning for all treatments that involve posteriors beams. There is a significant increase in skin dose that is dependent on the percentage of the beam passing through the couch and the angle of incidence.

A simple quality assurance test tool for the visual verification of light and radiation field congruent using electronic portal images device and computed radiography.

BACKGROUND: The radiation field on most megavoltage radiation therapy units are shown by a light field projected through the collimator by a light source mounted inside the collimator. The light field is traditionally used for patient alignment. Hence it is imperative that the light field is congruent with the radiation field. METHOD: A simple quality assurance tool has been designed for rapid and simple test of the light field and radiation field using electronic portal images device (EPID) or computed radiography (CR). We tested this QA tool using Varian PortalVision and Elekta iViewGT EPID systems and Kodak CR system. RESULTS: Both the single and double exposure techniques were evaluated, with double exposure technique providing a better visualization of the light-radiation field markers. The light and radiation congruency could be detected within 1 mm. This will satisfy the American Association of Physicists in Medicine task group report number 142 recommendation of 2 mm tolerance. CONCLUSION: The QA tool can be used with either an EPID or CR to provide a simple and rapid method to verify light and radiation field congruence.

Accelerated partial breast irradiation using external beam conformal radiation therapy: a review.

Lumpectomy followed by whole breast radiation therapy (i.e. breast conservation therapy (BCT)) is the standard of care for management of early stage breast cancer. However, its utilization has not been maximized because of a number of reasons including the logistic issues associated with the 5-6 weeks of radiation treatment. Also, pathological and clinical data suggest that most ipsilateral breast cancer recurrences are in the vicinity of the lumpectomy. Accelerated partial breast irradiation (APBI) is an approach that treats only the lumpectomy bed plus a 1-2 cm margin, rather than the whole breast with higher doses of radiation in a shorter period of time. There has been growing interest for APBI and various approaches have been developed and are under phase I-III clinical studies. This paper reviews external beam conformal radiation therapy (EBCRT) as a possible technique to APBI. The various EBCRT approaches such as 3D conformal radiation therapy, IMRT, proton therapy, tomotherapy, and volumetric arc therapy are discussed. Issues with the implementation of these techniques such as target volume delineation and organ motion are also presented. It is evident that EBCRT has potential for APBI of a selected group of early breast cancer patient. However, issues with setup errors and breathing motions need to be adequately addressed.

Accelerated Partial Breast Irradiation (APBI): A review of available techniques.

Breast conservation therapy (BCT) is the procedure of choice for the management of the early stage breast cancer. However, its utilization has not been maximized because of logistics issues associated with the protracted treatment involved with the radiation treatment. Accelerated Partial Breast Irradiation (APBI) is an approach that treats only the lumpectomy bed plus a 1-2 cm margin, rather than the whole breast. Hence because of the small volume of irradiation a higher dose can be delivered in a shorter period of time. There has been growing interest for APBI and various approaches have been developed under phase I-III clinical studies; these include multicatheter interstitial brachytherapy, balloon catheter brachytherapy, conformal external beam radiation therapy and intra-operative radiation therapy (IORT). Balloon-based brachytherapy approaches include Mammosite, Axxent electronic brachytherapy and Contura, Hybrid brachytherapy devices include SAVI and ClearPath. This paper reviews the different techniques, identifying the weaknesses and strength of each approach and proposes a direction for future research and development. It is evident that APBI will play a role in the management of a selected group of early breast cancer. However, the relative role of the different techniques is yet to be clearly identified.

Determination of the photon beam attenuation by the Brainlab imaging couch: angular and field size dependence.

Highly attenuating radiation treatment couches are no longer useful in the present era of radiotherapy utilizing IMRT and IGRT. Carbon fibers couch tops with its high tensile strength and low density present a useful alternative. The objective of the current study was to quantify the attenuation of megavoltage photons through a Brainlab imaging couch top and headrest at various angles and field sizes. At normal incidence, the couch attenuated 6 MV photons by 4.9% and 3.4% for 5 x 5 cm(2) and 10 x 10 cm(2) field sizes respectively. The headrest on the other hand only attenuated 6 MV photons by 2.5% and 1.6% respectively. There was no significant attenuation of the 18 MV beam by either the couch or the headrest. We found the attenuation to be dependent on the gantry angle, with the highest attenuation recorded at 1200. At this angle, the couch attenuated the 6 MV photon beam by 10% and 8.3% for the 5 x 5 cm(2) and 10 x 10 cm(2) field sizes respectively. Similarly, 18 MV photon beam was attenuated by 3.6% and 3.4% for the 5 x 5 cm(2) and 10 x 10 cm(2) field sizes at 1200 gantry angle. The highest attenuation for the headrest on the other hand occurred at 110 degrees gantry angle. For the 6 MV photon beam the headrest attenuation at this angle was 6.3% and 5.6% for the 5 x 5 cm(2) and 10 x 10 cm(2) field sizes respectively. Similarly for the 18 MV the attenuation was 2.3% and 2.1% 5 x 5 cm(2) and 10 x 10 cm(2) field sizes respectively. It apparent that the use of the Brainlab imaging couch and headrest in IMRT with posterior beams will results in significant decrease in the dose delivered to the target.

What are the standards by which bone mass measurement at peripheral skeletal sites should be used in the diagnosis of osteoporosis?

Measurement of bone mineral density (BMD) at central skeletal sites with dual X-ray absorptiometry is the "gold standard" both for the diagnosis of osteoporosis using the criteria of the World Health Organization (WHO) and for monitoring individuals receiving antiresorptive treatment for osteoporosis. Measurement of BMD at peripheral sites (peripheral BMD) can be used to assess fracture risk, but application of the WHO criteria gives different prevalence values for "osteoporosis" with peripheral devices, and different risks for fracture at the same cut points. The International Society for Clinical Densitometry Position Development Conference panelists reached the following conclusions about peripheral BMD testing: First, WHO T-score criteria should not be used with peripheral devices. Second, for the identification of a level for peripheral BMD measurements above which osteoporosis is unlikely, device-specific cut points for peripheral BMD should be identified that have 90% sensitivity for identifying patients who have osteoporosis (T-score of -2.5 or below) based on measurements of the spine and hip. If central BMD testing is available, patients who have peripheral BMD below the 90% sensitivity level should have a central BMD measurement. If central BMD testing is not available, peripheral BMD might be used for identification of patients who are likely to have osteoporosis. Risk-based cut points were preferred to prevalence based cut points, and, again, device-specific cut points are needed. For patients tested only with a peripheral BMD device whose result is intermediate, clinical judgment would be needed. Third, peripheral BMD testing should not be used for monitoring patients who are taking antiresorptive therapy for osteoporosis. Fourth, peripheral BMD testing performs best when used for postmenopausal women. Further research on all these issues is needed.