[Cost-benefit studies of 2 equivalent forms of therapy in cervical cancer in the pretherapeutic T 1b stage]. / Kosten-Nutzen-Untersuchungen zu zwei gleichwertigen Therapieformen beim Kollumkarzinom im prätherapeutischen Stadium T 1b.

Patients suffering from a collum carcinoma stage T 1b can be treated either by operation according to Wertheim and Meigs, or by radiotherapy. The results with regard to post operationem complications, five-year-survival and recidivation are equivalent in both methods. Therefore, an analysis of the indirect benefit and the costs of both therapies was performed. Surgery was superior to radiotherapy in all analysed dimensions of indirect benefit. Over and above this, expenses for an operation were 2.7 times lower than for radiotherapy.

Carcinoma of the cervix stage T1b. A 15 years review of 256 cases.

256 patients of the years 1965-1979 who suffered from collum carcinoma stage T1b were reviewed. Most of the neoplasmas were squamous cell carcinoma (81%). By tumor screening only 21% of the carcinomas were detected. The treatment was in most of the cases a radical hysterectomy (Wertheim-Meigs). Postoperative radiotherapy was performed in cases of poor differentiated carcinoma of if lymphatic nodes had been occupied by the tumor. Thus only 43 patients had no radiotherapy. A 5 year-follow-up was possible in 151 cases. Women older than 40 year showed a better prognosis than younger women. Patients treated only by radiotherapy had a five year survival rate of 88%. No difference in prognosis was observed, if radiotherapy was additionally performed. There was no significant difference of severe complications in either forms of treatment.

[Spontaneous rupture of a deciduoma with intra-abdominal hemorrhage]. / Spontanruptur eines Deziduoms mit intraabdominaler Blutung.

A so-called Deciduoma caused severe intraabdominal haemorrhage in third trimester of pregnancy. The bleeding from the hypervascular tumor resulted in the decompensation of balanced placental insufficiency and thus led to fetal distress.

[Cervical carcinoma in the T1b stage. Therapy, complications and prognosis]. / Das Zervixkarzinom im Stadium T1b. Therapie, Komplikationen und Prognose.

Records of 256 patients with carcinoma of the cervix uteri stage T1b from the years 1965-1979 were reviewed retrospectively. By screening programs only 21% were detected. Most of the neoplasms were squamous cell carcinoma (81%). The majority of the patients was treated surgically most frequently by radical hysterectomy (Wertheim-Meigs). If the carcinoma was poorly differentiated and/or lymphonodi were positive postoperative radiotherapy was added. Thus only 43 patients had no radiotherapy. 5 year survival rate could be studied in 151 patients. 89% survived 5 years or more following primary treatment. Older women (over 40 years old) showed a better prognosis than those below 40. Patients treated by radiotherapy alone survived 5 years in 88 per cent. Patients treated by radical hysterectomy had a five year survival rate of 94.6%. No difference in prognosis was observed, if radiotherapy was added. There was no significant difference in the frequency of severe complications in both kinds of treatment. The rate of recurrencies was 9.4 per cent.

[Morphometric placental investigations in EPH-gestosis (pre-eclampsia) (author's transl)]. / Morphometrische Placentaberfunde bei EPH-Gestose.

Morphometric data of 19 placenta after EPH-gestosis of pregnancy are compared with data of placenta of uncomplicated pregnancies. No statistically significant differences were found concerning the area of attachment of the placentas, the amount of fibrin deposits in the intervillous space and the amount of syncytial knots of the terminal villi. The areas of the cross section as well as the circumferences of the resorption villi were increased in the placentas of pre-eclampsia of pregnancy. The number of capillaries per villus was the same in both groups. The diameters of the vessels however were smaller in the gestosis group. Also a decrease of the degree of vascularisation of the villi was found. The number and length of epithelial plates and their quota of the circumference of the villi were markedly diminished in the EPH-gestosis group. These morphologic findings are signs of retarded maturation (differentiation) of the resorption villi. The results explain the ineffectiveness of therapeutic attempts in many cases of pre-eclampsia.

[Morphometric studies in placental villi of mature human placentas (author's transl)]. / Morphometrische Untersuchungen an Plazentazotten reifer menschlicher Plazenten.

In 56 placentas from uncomplicated pregnancies and normal spontaneous deliveries at term were investigated. Mature placental villi situated in the periphery of placentones (fetomaternal circulation units) were measured. The contents of intervillous fibrinoid was determined as well as the number of syncytial knots. Automatic ("TAS" Leitz, West Germany and Videmat "Zeiss", West Germany) and semiautomatic ("MOP AM 01" Kontron, West Germany) planimeters were used. Some of the results could be compared with earlier results published in the literature so far. The "normal values" revealed in normal term placentas will be compared with placentas of pathologic pregnancies in consecutive studies.