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Org Biomol Chem
; 14(36): 8448-8451, 2016 Sep 14.
Article
in English
| MEDLINE
| ID: mdl-27722410
ABSTRACT
The regioselective ethoxyiodination of enamides was developed using PIFA in combination with potassium iodide in ethanol. The reaction proceeds regioselectively with excellent yields and diastereoselectivities, providing valuable synthons for further functionalisations. Control experiments were conducted, indicating that the transformation occurs through an ionic manifold involving an in situ generated hypoiodite species.