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1.
Rinsho Ketsueki ; 57(5): 602-7, 2016 05.
Article in Japanese | MEDLINE | ID: mdl-27263785

ABSTRACT

A 75-year-old woman presented with edema of the left leg in December 2012. On examination, there was a palpable 5-cm tumor in the left lower abdomen, and PET/CT showed lymphadenopathy of the tracheal, para-aortic, left iliac and inguinal regions with increased FDG uptake. We performed histopathological examination of the iliac lymph node and diagnosed diffuse large B-cell lymphoma (DLBCL), stage IIIA. The patient received 8 courses of R-CHOP chemotherapy and achieved a complete response. In April 2014, she noticed seven new painful erythematous vesicles <1 cm in size on the skin of the left lower abdominal region. Herpes zoster was suspected and valacyclovir was administered. However, this medication had no effect, and the vesicles enlarged and became nodular. Histopathological examination of one of the skin lesions revealed the infiltration of DLBCL and the diagnosis of zosteriform cutaneous recurrence of DLBCL was thus made. Skin lesions mimicking herpes zoster have been reported in certain types of hematological malignancies, and histopathological diagnosis should be performed in such cases.


Subject(s)
Diagnosis, Differential , Herpes Zoster/diagnosis , Lymphoma, Large B-Cell, Diffuse/pathology , Skin Neoplasms/pathology , Acyclovir/analogs & derivatives , Acyclovir/therapeutic use , Aged , Antibodies, Monoclonal, Murine-Derived/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Antiviral Agents/therapeutic use , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Female , Herpes Zoster/drug therapy , Humans , Lymphoma, Large B-Cell, Diffuse/drug therapy , Prednisone/therapeutic use , Recurrence , Rituximab , Skin Neoplasms/drug therapy , Treatment Outcome , Valacyclovir , Valine/analogs & derivatives , Valine/therapeutic use , Vincristine/therapeutic use
2.
Intern Med ; 52(1): 129-33, 2013.
Article in English | MEDLINE | ID: mdl-23291688

ABSTRACT

We herein report the case of a 77-year-old man admitted for an acute cutaneous infection and persistent fever. A physical examination revealed systemic small blisters and scrotal swelling. He was suspected of having complications from chickenpox or bullous impetigo as the initial diagnosis. Nocardia was detected on an aspiration biopsy of the small blisters and the surgically removed testis at a later date. Testicular nocardiosis is a rare condition; however, we should consider nocardiosis in the differential diagnosis because delay in providing treatment may worsen a patient's general condition.


Subject(s)
Nocardia Infections/diagnosis , Nocardia/isolation & purification , Skin Diseases, Bacterial/diagnosis , Testis/microbiology , Aged , Biopsy, Needle , Follow-Up Studies , Humans , Immunohistochemistry , Infusions, Intravenous , Male , Meropenem , Nocardia Infections/drug therapy , Rare Diseases , Skin Diseases, Bacterial/drug therapy , Testis/pathology , Thienamycins/therapeutic use , Treatment Outcome
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