[The prevention of the hypercoagulation syndrome during the combined treatment of lung cancer patients using artificial hyperglycemia]. / Profilaktika giperkoaguliatsionnogo sindroma pri kombinirovannom lechenii bol'nykh rakom legkogo s ispol'zovaniem iskusstvennoi giperglikemii.

Status of hemostasis system and occurrence of postoperative thromboembolic complications were assessed in 246 lung cancer patients in whom combined treatment included artificial hyperglycemia. The latter condition contributed to higher blood coagulability resulting in lung artery thromboembolism in some cases. Administration of a combination of heparin, curantil and nicotinic acid was followed by a decrease in blood coagulability, increase in anticoagulation function, decrease in platelet aggregability, activation of fibrinolysis and regression of biochemical signs of DIC syndrome thereby assuring a drop in the occurrence of thromboembolic complications.

[Infusion therapy in sessions of general artificial hyperthermia using large doses of insulin in cancer patients]. / Infuzionnaia terapiia pri seansakh obshchei iskusstvennoi gipertermii s primeneniem bol'shikh doz insulina u onkologicheskikh bol'nykh.

A scheme of infusion correction of water-electrolyte shifts occurring during general artificial hyperthermia sessions (rectal t degrees-40-42 degrees C) employing large insulin doses (100-1120 U) in cancer patients has been suggested. The infusion therapy according to the technique described was used during 103 general artificial hyperthermia sessions in 58 patients. This made it possible to maintain physiologically normal blood plasma levels of glucose, Na+, K+, calcium, inorganic phosphates, normal acid-base balance, adequate hydration and circulating blood volume.

[Whole-body artificial controlled hyperthermia and hyperglycemia in the combined treatment of metastatic kidney cancer]. / Obshchaia iskusstvennaia upravliaemaia gipertermiia i giperglikemiia pri kompleksnom lechenii metastaticheskogo raka pochki.

The attempt of treatment for metastatic renal cancer has not been a success as all the methods known failed to produce any significant effect on the development of metastases. So the search for the means which could potentiate the antitumor activity of the drugs or radiation therapy is still a problem. Various physicochemical methods, including hyperthermia and hyperglycemia, have been used as modifiers of tumor cell responses. When properly employed, hyperthermia and hyperglycemia can produce an antitumor effect. However, their ability to selectively potentiate radiation or chemotherapy is more valuable. A total of 25 patients with renal cell carcinoma and multiple metastases have undergone a comprehensive treatment: radiation therapy for metastases at the total dosage of 60 Gr after removal of the primary tumor. The session of hyperthermia and hyperglycemia was performed in the course of the radiation therapy. During the session chemotherapeutic agents were administered in a half-course dosage. The second part of the radiation therapy was continued after the session. The treatment course included 5 sessions and lasted 12 months. An immediate stabilization of the health status was recorded in all the patients. Some of them had the total or partial regression of metastases. Yet since the follow-up time was not long the authors could make no conclusions.

[Effects of induced hyperglycemia on the activity of pancreatic and gastrointestinal secretion of hormones in oncologic patients]. / Vliianie iskusstvennoi giperglikemii na aktivnost' pankreaticheskoi i gastrointestinal'noi sekretsii gormonov u onkologicheskikh bol'nykh.

Artificial hyperglycemia (AHG) used in the cancer treatment considerably increases the insulin and S-peptide content in blood, decreases the glucagon concentration and tissue glucose tolerance. The changes are reversible, have a functional character, that indicates the absence of a disbalance in hormonal mechanisms of carbohydrate metabolism control as well as marked disorders of the pancreas function. In order to achieve a wider range of indications for using AHG in complex schemes of the cancer treatment, it is necessary to take measures on optimization of the carbohydrate metabolism state which should be controlled by the suggested complex of laboratory tests.

[Prevention of postoperative phlebothrombosis of the legs using low-dose heparin in urologic patients]. / Profilaktika posleoperatsionnogo flebotromboza nizhnikh konechnostei malymi dozami geparina u urologicheskikh bol'nykh.

Deep vein thrombosis of low extremities is the commonest complication in postsurgical urology. Difficult for diagnosis it induces thromboembolism of pulmonary artery contributing from 11.1 to 66 per cent to the rate of total postsurgical mortality. Possibility of solving the problem depends strongly on the development of efficient technique of phlebothrombosis prevention. The paper deals with the corresponding research conducted in 202 urologic patients aged from 40 to 90 years. The control group (108 persons) was subjected to routine nonspecific methods of thromboembolism prevention. The research group (94 patients) was additionally prone to the treatment with low dosages of heparin. The effect of the treatment was assessed with 125I-fibrinogen radionuclide test. Low-dosage heparin treatment resulted in a 3.3-fold decrease in the number of patients who developed postsurgery phlebothrombosis of low extremities. Incidence of thrombosis in them was 4.2-fold lower. Besides, there was a reduction in bilateral and macrofocal thrombosis incidence (11 and 11.5 times as less, respectively). The effect of the chemotherapy closely correlated with the pattern of surgical intervention and the dosage of the drug used. Low dosages of heparin (10,000 U per 24 hrs) administered to the patients with adenectomized prostate resulted in a 2.1-fold decrease in the number of those who developed deep venous thromboses of low extremities and a 3.4-fold decrease in the number of thrombosed extremities as low-dosage heparin treatment significantly influenced the incidence of bilateral thrombosis. When used as 15,000 U per 24 hrs in those patients who were exposed to lithotomy or nephrectomy the drug led to a 5-fold decrease in the incidence of phlebothrombosis.(ABSTRACT TRUNCATED AT 250 WORDS)

[Antiarrhythmic therapy in extreme conditions of artificial whole-body hyperthermia and artificial hyperglycemia in cancer patients]. / Antiaritmicheskaia terapiia v ékstremal'nykh rezhimakh iskusstvennoi obshchei gipertermii i isskustvennoi giperglikemii u onkologicheskikh bol'nykh.

It has been shown that sessions of total body hyperthermia (rectal temperature - 40.0-41.8 degrees C) and artificial hyperglycemia (22-23 mmol/l) in combination with chemotherapy in cancer patients with severe cardiac arrhythmias should follow antiarrhythmic pretreatment and should be accompanied by injections of lidocaine and lidocaine combined with amiodarone, that in most cases prevent or arrest life-threatening cardiac arrhythmias.

[Immediate results of surgical and combined treatment of patients over 60 years of age with cancer of the uterine body]. / Neposredtvennye rezul'taty khirurgicheskogo i kombinirovannogo lecheniia bol'nykh rakom tela matki starshe 60 let.

The paper discusses the results of long-term investigations of application of surgery for endometrial carcinoma in patients aged 60-84 years. Intraoperative lethality was 0.2% [corrected], postoperative--0.8%. Surgical treatment proved safe. Suggestions were made to use it in a wider range of indications in older patients. Its application, however, requires careful preoperative preparation, adequate extent of tumor excision, fine surgical technique and effective postoperative intensive care.

[Allergic heparin-induced infiltrates and skin necrosis caused by subcutaneous injections of heparin]. / Allergicheskie geparinovye infil'traty i nekrozy kozhi, vyzvannye podkozhnym primeneniem geparina.

Application of heparin in low doses to the treatment of 6 patients to prevent postoperative venous thromboembolic complications led to the development of an allergic heparin infiltrate (AHI). In three cases, the AHI eventuated in skin and subcutaneous fat necrosis, while in the remaining cases, underwent a reverse development. Apparently, the basis of the AHI is formed by the immediate type hypersensitivity developing in the area of repeated heparin injections. The AHI should be treated with glucocorticoids, antihistamine drugs, and antibiotics.

[Treatment of the complications occurring in BCG vaccine immunotherapy of patients with malignant neoplasms]. / Lechenie oslozhnenii, voznikaiushchikh pri immunoterapii vaktsinoi BTsZh bol'nykh zlokachestvennymi novoobrazovaniiami.

The results of nonspecific immunotherapy with BCG vaccine in 98 cases of melanoma, breast cancer and other malignancies were used in evaluating the frequency and degree of side-effects and complications arising in cancer patients during this treatment. The procedure proved to be safe irrespective of patients' age. Prevention and treatment of side-effects such as fever, water-salt disorders, anorexia, interstitial hepatitis and promotion of tumor growth are discussed.

[Postoperative thrombosis of the deep veins of the legs in cancer patients]. / Posleoperatsionnyi tromboz glubokikh ven golenei u onkologicheskikh bol'nykh.

Postoperatively, 50 oncogynecological patients were examined with J125 fibrinogen, and thrombosis of profound crural veins was noted in 62% of them. The thrombosis mostly frequently occurred on both extremities and in the median crus, there is a tendency to its expansion in 40.7% of cases. Four patients with thrombosis of profound crural veins showed the development of thromboembolism of the pulmonary artery branches. Under consideration is the cause of thrombi formation in oncogynecological patients and the role of the former in the genesis of embolic complications.

[Radioisotope diagnosis of postoperative deep-vein thrombosis of the leg in oncological patients]. / Radioizotopnaia diagnostika posleoperatsionnogo tromboza u onkologicheskikh bol'nykh.

The authors have studied the frequency and characteristic features of postoperative thrombosis of profound crural veins (PTPCV), using the method of radioindication with fibrinogen J125. Among 80 oncological patients PTPCV), was found in 47 (58.7%). It is noted that PTPCV in 92% of cases developed during 5 days postoperatively, bilateral involvement is more frequently observed (70.2%), and in 28.7% of cases thrombosis involved the upper crural third. Clinical signs of PTPCV were revealed only in 44% of cases and, on the average, 2 days following the onset of the thrombotic process. Radioindication of PTPCV with fibrinogen J125 is a simple, early and precise method of establishing the diagnosis of theis postoperative complications.