18F-fluorodeoxyglucose positron-emitted tomography for predicting neurological outcome in hypoxic-ischemic encephalopathy.

Background: 18F-fluorodeoxyglucose positron-emitted tomography (FDG-PET) is a promising yet unexplored functional neuroimaging tool in the study and prognosis of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest or respiratory failure. The present study aimed to correlate clinical data and FDG-PET scans for both analysis and prognostic use. Methods: 24 patients from an intensive rehabilitation ward were retrospectively evaluated. Data collected included age, gender, cause of anoxic event, length of stay in acute and rehabilitation units, discharge destination, and evaluation at admission and discharge using three clinical scales to assess cognitive function, independence and disability. Subjects were identified as good and bad performers on the basis of quantitative analysis of FDG-PET scans with the Cortex ID software. The relation between glucose uptake reduction and neurological outcome was evaluated. Results: good and bad performers presented no statistically significant difference regarding demographical data and in-hospital length of stay. The two categories significantly differed for impairment and disability levels both at admission and at discharge from the inpatient rehabilitation unit. Conclusions: FDG-PET considerably facilitates the early identification of patients with HIE who will have poor neurological outcome and could inform planning for their rehabilitation and care.

Analysis of Dental Malocclusion and Neuromotor Control in Young Healthy Subjects through New Evaluation Tools.

The presence of a correlation between stomatognathic and postural systems has been investigated by different authors trying to identify a possible influence of dental occlusion on body posture and balance. The aim of this study was to evaluate the relationship between dental occlusion and neuromuscular control in a healthy young population using modern evaluation tools. 25 subjects (9 males and 16 females, aged 23 to 44) were evaluated for dental occlusion, particularly in relation to overjet and overbite parameters, anterior and posterior crossbite, scissor bite, mandibular crowding, molar and canine class, and deviation of the median dental line. Neuromotor control was assessed using two different types of stabilometric platforms in both monopodalic and bipodalic equilibriums (Prokin-B and MF-Stability, Tecnobody, Italy). All subjects were evaluated with and without cotton rolls positioned between the upper and lower arches at the premolar level in order to temporarily eliminate any pathological contact. In all 25 subjects, no statistically significant differences were revealed between the evaluations performed with and without cotton rolls in all the analyzed conditions (in static, in dynamics, with open and closed eyes). This study did not find a significant correlation between dental occlusion and neuromuscular control in a young and healthy population.