ABSTRACT
Abstract Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.
Subject(s)
Humans , Male , Child , Skin/pathology , Linear IgA Bullous Dermatosis/pathology , Basement Membrane/pathology , Biopsy , Skin Diseases, Vesiculobullous/pathology , Fluorescent Antibody Technique, Direct , Erythema/pathologyABSTRACT
Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.
Subject(s)
Linear IgA Bullous Dermatosis/pathology , Skin/pathology , Basement Membrane/pathology , Biopsy , Child , Erythema/pathology , Fluorescent Antibody Technique, Direct , Humans , Male , Skin Diseases, Vesiculobullous/pathologySubject(s)
Genital Diseases, Female/pathology , Lichen Sclerosus et Atrophicus/pathology , Biopsy , Child , Female , Humans , Skin/pathologyABSTRACT
Progressive symmetrical erythrokeratodermia is a rare autosomal dominant genodermatosis with variable penetrance described by Darier in 1911. It is characterized by erythematous and keratotic plaques, sharply defined and symmetrically distributed along the extremities, buttocks and, more rarely, on the face. We report a case of a 55-year-old patient with lesions on the dorsum of the hands, interphalangeal pads, wrists, groin and back feet. This case demonstrates a rare and late diagnosis, clinical profusion and presence of familiar involvement.
Subject(s)
Erythrokeratodermia Variabilis/pathology , Keratoderma, Palmoplantar/pathology , Acitretin/therapeutic use , Erythrokeratodermia Variabilis/drug therapy , Female , Humans , Keratoderma, Palmoplantar/drug therapy , Keratolytic Agents/therapeutic use , Middle AgedABSTRACT
Cutaneous endometriosis is a rare manifestation of endometriosis, representing 0.5% to 1% of all endometriosis cases. It can be divided into primary and secondary, when appearing spontaneously or after a surgical procedure, when it is mostly found on surgical scar tissue. Some etiologies were proposed, but none of them could entirely explain the appearance of the tumor. Differential diagnosis includes melanoma, metastatic nodule, keloid and pyogenic granuloma. Dermoscopic features are not yet well established, but there are some characteristics that suggest the diagnosis. Treatment is surgical in larger sized lesions. Malignization can occur. The screening for endometriosis is mandatory by means of gynecologic, imaging and marked-tumor evaluation. We report a case of primary umbilical endometriosis and discuss its dermoscopic aspects.
