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1.
Biochem Biophys Res Commun ; 514(1): 246-251, 2019 06 18.
Article in English | MEDLINE | ID: mdl-31029428

ABSTRACT

Due to the increasing focus on aging as an important risk factor for many serious diseases and an emphasis on animal models that have translational value, an increasing number of animal models are being aged. Animal behavior tests can be used to assess effects of aging in mouse models. Female mice begin exhibiting anxiety-like behaviors at 12 months of age which become more serious at 24 months, while males exhibit no age-induced anxiety-like behaviors. Males and females equally demonstrate a failure of daily task performance at 24 months. Despite these cognitive changes, the mice do not show changes in gross motor function. These results suggest cognitive impairment in non-genetically modified aging mice.


Subject(s)
Aging/physiology , Anxiety/etiology , Behavior, Animal , Aging/psychology , Animals , Body Weight , Female , Male , Mice, Inbred C57BL , Motor Activity , Nesting Behavior/physiology , Task Performance and Analysis
2.
Sci Adv ; 3(12): e1700443, 2017 12.
Article in English | MEDLINE | ID: mdl-29255798

ABSTRACT

Seismicity in the U.S. midcontinent has increased by orders of magnitude over the past decade. Spatiotemporal correlations of seismicity to wastewater injection operations have suggested that injection-related pore fluid pressure increases are inducing the earthquakes. We present direct evidence linking earthquake occurrence to pore pressure increase in the U.S. midcontinent through time-lapse shear-wave (S-wave) anisotropy analysis. Since the onset of the observation period in 2010, the orientation of the fast S-wave polarization has flipped from inline with the maximum horizontal stress to inline with the minimum horizontal stress, a change known to be associated with critical pore pressure buildup. The time delay between fast and slow S-wave arrivals exhibits increased variance through time, which is common in critical pore fluid settings. Near-basement borehole fluid pressure measurements indicate pore pressure increase in the region over the earthquake monitoring period.

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