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J Nat Med ; 63(3): 355-9, 2009 Jul.
Article in English | MEDLINE | ID: mdl-19387769

ABSTRACT

The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.


Subject(s)
Enzyme Inhibitors/pharmacology , Eugenol/analogs & derivatives , Piper betle/chemistry , Plant Extracts/chemistry , Plant Leaves/chemistry , Xanthine Oxidase/antagonists & inhibitors , Enzyme Inhibitors/chemistry , Eugenol/chemistry , Eugenol/pharmacology , Molecular Structure
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