ABSTRACT
PURPOSE: Toevaluate the effect of removing epiretinal membranes (ERMs) on visual function and vision-related quality of life (VR-QOL) for 12 months postoperatively. METHODS: Idiopathic ERMs were removed during vitrectomy in 26 eyes. The VR-QOL was evaluated using a self-administered 25-item National Eye Institute Visual Function Questionnaire before (baseline) and 3 and 12 months postoperatively. During the same periods, the best-corrected visual acuity (BCVA), central macular thickness (CMT), and metamorphopsia score were recorded. RESULTS: At baseline and months 3 and 12, the logMAR BCVAs (mean ± SEM) were 0.41 ± 0.05, 0.17 ± 0.04 (P = 0.0001 versus baseline), and 0.10 ± 0.03 (P < 0.0001 versus baseline, P = 0.0016 versus month 3), respectively; the CMTs (µm) were 402 ± 18, 312 ± 9 (P < 0.0001 versus baseline), and 300 ± 7 (P < 0.0001 versus baseline, P = 0.0544 versus month 3); and the metamorphopsia scores were 202 ± 29, 137 ± 27 (P = 0.0186 versus baseline), and 108 ± 26 (P = 0.0005 versus baseline, P = 0.0218 versus month 3). In 23 (88%) of 26 eyes, the BCVA improved more than 0.1 logMAR unit at month 12. The improved BCVA was correlated with improvements in two subscales (r = -0.405 to -0.574, P = 0.0041-0.0427) at month 3; the improved metamorphopsia score was correlated with the improved composite score (r = -0.552, P = 0.0058) and three subscales (r = -0.458 to -0.507, P = 0.0113-0.0219) at month 12. CONCLUSIONS: Removing ERMs improved visual function, anatomy, and the VR-QOL. Three months postoperatively, the improved BCVA was the most important factor related to the improved VR-QOL, although the simultaneous cataract surgery might have had a confounding effect. The improved metamorphopsia was the important factor associated with improved VR-QOL 12 months postoperatively.(www.umin.ac.jp/ctr number, UMIN000000617).
Subject(s)
Epiretinal Membrane/surgery , Quality of Life , Visual Acuity , Vitrectomy , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Macula Lutea/pathology , Male , Middle Aged , Prospective Studies , Surveys and Questionnaires , Tomography, Optical Coherence , Vision Disorders/surgerySubject(s)
Aqueous Humor/metabolism , Crystallins/metabolism , Eye Injuries/diagnosis , Lens, Crystalline/injuries , Uveitis/diagnosis , Wounds, Nonpenetrating/diagnosis , Adult , Blotting, Western , Eye Injuries/metabolism , Female , Humans , Lens, Crystalline/metabolism , Uveitis/etiology , Uveitis/metabolism , Wounds, Nonpenetrating/metabolismSubject(s)
Amyloidosis/complications , Intraocular Pressure , Ocular Hypotension/etiology , Retinal Detachment/etiology , Retinal Hemorrhage/etiology , Trabeculectomy/adverse effects , C-Reactive Protein/metabolism , Female , Glaucoma/surgery , Humans , Middle Aged , Ocular Hypotension/physiopathology , Retinal Detachment/physiopathology , Retinal Hemorrhage/physiopathology , Serum , Serum Amyloid A Protein/metabolismABSTRACT
PURPOSE: To propose a new surgical technique for optimized visualization of the chamber angle using scleral indentation under an operating microscope in goniosynechialysis (GSL). PATIENTS AND METHODS: Six volunteers with normal chamber angle and five patients with synechial angle closure glaucoma were examined. Scleral indentation 2 mm posterior to the limbus was performed during observation of chamber angle. Width of trabecular meshwork in images was recorded through a CCD camera mounted on an operating microscope. Trabecular-iris angle and trabecular-corneal angle obtained by ultrasound biomicroscopy were used for the parameters for the angle configuration. GSL with scleral indentation was performed in the patients. RESULTS: According to the visibility of the chamber angle, width of trabecular meshwork in images significantly increased from 0.34 +/- 0.08 mm equivalent (mean +/- SD) to 0.67 +/- 0.14 mm equivalent (P = 0.0001) with scleral indentation. According to the angle configurations, trabecular-iris angle significantly increased from 39.6 +/- 3.8 degrees to 47.5 +/- 6.6 degrees (P = 0.0016), and trabecular-corneal angle significantly decreased from 169.8 +/- 5.5 degrees to 158.7 +/- 5.4 degrees (P < 0.0001). All patients were successfully treated with GSL using scleral indentation. CONCLUSION: Scleral indentation provided the surgeon an optimized visualization of the anterior chamber angle. Deepening of the chamber angle and steeping in trabecular-corneal curvature probably induced the plane of the trabecular meshwork less oblique to the surgeon's visual axis. This enhanced visualization promises the accuracy and safety of GSL.
