1.
Bioorg Med Chem Lett
; 12(1): 5-8, 2002 Jan 07.
Article
in English
| MEDLINE
| ID: mdl-11738561
ABSTRACT
This communication describes the synthesis and in vitro evaluation of a novel and potent series of phthalazine phosphodiesterase type (IV) (PDE4) inhibitors. The interaction with two distinct polar binding sites allowed us to eliminate the cyclopentyloxy substitution from rolipram-like analogues.