Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Bioorg Med Chem ; 12(5): 1151-75, 2004 Mar 01.
Article in English | MEDLINE | ID: mdl-14980627

ABSTRACT

A series of 3-mercapto-propionic acid derivatives that function as reversible inhibitors of carboxypeptidase U have been prepared. We present a successful design strategy using cyclic, low basicity guanidine mimetics resulting in potent, selective and bioavailable inhibitors of carboxypeptidase U (TAFIa).


Subject(s)
3-Mercaptopropionic Acid/chemical synthesis , Carboxypeptidase B2/antagonists & inhibitors , Enzyme Inhibitors/chemical synthesis , 3-Mercaptopropionic Acid/pharmacology , Administration, Oral , Biological Availability , Drug Design , Enzyme Inhibitors/pharmacology , Guanidine , Humans , Inhibitory Concentration 50 , Molecular Mimicry , Structure-Activity Relationship
SELECTION OF CITATIONS
SEARCH DETAIL
...