ABSTRACT
Appendiceal mucocele represents specimen finding in 0.2-0.3% out of appendectomies. The rupture or perforation in peritoneal cavity might cause pseudomixoma peritonei (PMP), with multiple mucinous deposits in the abdominal cavity. We report a case of PMP caused by a perforated appendiceal cistoadeonoma.
Subject(s)
Appendiceal Neoplasms/complications , Cystadenoma, Mucinous/complications , Mucocele/complications , Pseudomyxoma Peritonei/etiology , Aged , Appendiceal Neoplasms/diagnostic imaging , Cystadenoma, Mucinous/diagnostic imaging , Humans , Laparoscopy , Male , Mucocele/diagnostic imaging , Rupture, Spontaneous/complications , Rupture, Spontaneous/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Merkel cell carcinoma (MCC) of the skin is a rare but aggressive cutaneous neuroendocrine-derived malignancy that predominantly affects elderly white males. The presence of distant nodal metastases significantly impacts survival. Typical metastatic sites of MCC are liver, bone, brain and skin. Gastrointestinal metastases are uncommon and small bowel is the most common site followed by stomach. We report a case of symptomatic MCC jejunal metastasis.
Subject(s)
Carcinoma, Merkel Cell/secondary , Jejunal Neoplasms/secondary , Skin Neoplasms , Aged , Carcinoma, Merkel Cell/diagnostic imaging , Carcinoma, Merkel Cell/pathology , Female , Humans , Jejunal Neoplasms/diagnostic imaging , Jejunal Neoplasms/pathology , Magnetic Resonance Imaging , Skin Neoplasms/pathologyABSTRACT
We propose a mathematical model for the transport of DNA plasmids from the extracellular matrix up to the cell nucleus. The model couples two phenomena: the electroporation process, describing the cell membrane permeabilization to plasmids and the intracellular transport enhanced by the presence of microtubules. Numerical simulations of cells with arbitrary geometry, in 2D and 3D, and a network of microtubules show numerically the importance of the microtubules and the electroporation on the effectiveness of the DNA transfection, as observed by previous biological data. The paper proposes efficient numerical tools for forthcoming optimized procedures of cell transfection.
