ABSTRACT
Non-ossifying fibromas (NOF) are a benign entity of the developing bone, relatively common in children and young adults. Their location is most frequently metaphyseal. They are usually asymptomatic (unless associated to a fracture) and have a self-limited behavior, with spontaneous regression through a sclerotic consolidation. Plain X-ray is the main imaging tool for its diagnosis. However, an unclear X-ray may lead to further imaging studies. We present the case of a 17-year-old male with back pain and lower limb dysmetria referred for a bone scintigraphy to complete the diagnostic and assess disease extension and the subsequent MRI evaluation.
Subject(s)
Bone Neoplasms/diagnostic imaging , Fibroma/diagnostic imaging , Neoplasms, Multiple Primary/diagnostic imaging , Single Photon Emission Computed Tomography Computed Tomography , Tibia/diagnostic imaging , Adolescent , Humans , Magnetic Resonance Imaging , MaleABSTRACT
AIM: To assess the influence of time on the reliability of sentinel lymph node biopsy (SLNB) in breast cancer patients with previous excisional biopsy (EB), analyzing both the sentinel lymph node detection and the lymph node recurrence rate. MATERIAL AND METHODS: Thirty-six patients with cT1/T2 N0 breast cancer and previous EB of the lesion underwent a lymphoscintigraphy after subdermal periareolar administration of radiocolloid, the day before SLNB. Patients were classified into two groups, one including 12 patients with up to 29 days elapsed between EB and SLNB (group A), and another with the remaining 24 in which time between both procedures was of 30 days or more (group B). Scintigraphic and surgical detection of the sentinel lymph node, histological status of the sentinel lymph node and of the axillary lymph node dissection, if performed, and lymphatic recurrences during follow-up, were analyzed. RESULTS: Sentinel lymph node visualization at the lymphoscintigraphy and surgical detection were 100% in both groups. Histologically, three patients showed macrometastasis in the sentinel lymph node, one from group A and two from group B. None of the patients, not even those with malignancy of the sentinel lymph node, relapsed after a medium follow-up of 49.5 months (24-75). CONCLUSION: Time elapsed between EB and SLNB does not influence the reliability of this latter technique as long as a superficial injection of the radiopharmaceutical is performed, proving a very high detection rate of the sentinel lymph node without evidence of lymphatic relapse during follow-up.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/secondary , Lymphatic Metastasis/diagnostic imaging , Sentinel Lymph Node Biopsy , Sentinel Lymph Node/pathology , Aged , Axilla , Biopsy , Carcinoma, Ductal, Breast/diagnostic imaging , Carcinoma, Lobular/diagnostic imaging , Carcinoma, Lobular/secondary , Female , Follow-Up Studies , Humans , Injections, Subcutaneous , Lymphoscintigraphy , Middle Aged , Radiopharmaceuticals/administration & dosage , Recurrence , Reproducibility of Results , Retrospective Studies , Sentinel Lymph Node/diagnostic imaging , Technetium Tc 99m Aggregated Albumin/administration & dosage , Time FactorsABSTRACT
AIM: To evaluate the usefulness of the (75)SeHCAT abdominal retention (AR) measurement in the early diagnosis of diarrhea syndrome (DS). METHODS: Thirty-seven patients with diarrhea syndrome within the first month of evolution were prospectively evaluated. The (75)Se-SeHCAT abdominal retention was measured 4 and 7 days post-administration of 0.01 mCi of (75)SeHCAT. The test was performed prior to treatment and at 3 months when the baseline study was positive. The test was considered positive if the RA was <25% at 4(th) and <10% on the 7th day. The patients were visited at 3 months. Depending on the response, 3 groups were established: a) complete response: normalization of stool frequency, b) partial response, decrease of frequency or c) no response. RESULTS: Group A: The AR of (75)Se-SEHCAT was normal in 21 patients. Six were diagnosed of colonic diverticulosis, 8 of irritable bowel syndrome, 1 of lymphocytic colitis, 1 of post-gastroenteritis syndrome, 1 of celiac disease and 1 of stenosis of the cardia. Four are still under study. Group B: The AR of (75)Se-SEHCAT decreased in 16 patients. All showed abnormal AR at day 7 and all but 1 at day 4. Following administration of cholestyramine resin, 8 (50%) presented partial response and 8 (50%) complete response. At 3 months, AR had increased at day 4 and 9 at day 7. CONCLUSION: The measurement of (75)SEHCAT abdominal retention allows the early diagnosis of bile acid malabsorption in 43% of the patients with DS. Measurement at 7 days seems more accurate than that at 4 days.
Subject(s)
Diarrhea/diagnostic imaging , Malabsorption Syndromes/diagnostic imaging , Radiopharmaceuticals , Selenium Radioisotopes , Taurocholic Acid/analogs & derivatives , Abdomen/diagnostic imaging , Adult , Aged , Aged, 80 and over , Anticholesteremic Agents/therapeutic use , Cardia/pathology , Celiac Disease/complications , Celiac Disease/diagnosis , Cholestyramine Resin/therapeutic use , Chronic Disease , Colitis, Lymphocytic/complications , Colitis, Lymphocytic/diagnosis , Constriction, Pathologic , Diarrhea/diagnosis , Diarrhea/drug therapy , Diarrhea/etiology , Diarrhea/metabolism , Diverticulosis, Colonic/complications , Diverticulosis, Colonic/diagnosis , Early Diagnosis , Female , Humans , Intestinal Absorption , Irritable Bowel Syndrome/complications , Irritable Bowel Syndrome/diagnosis , Malabsorption Syndromes/etiology , Male , Middle Aged , Prospective Studies , Radionuclide Imaging , Radiopharmaceuticals/pharmacokinetics , Selenium Radioisotopes/pharmacokinetics , Taurocholic Acid/pharmacokinetics , Tissue DistributionABSTRACT
Objetivo. Investigar la relación entre el estado pre o posmenopáusico de la paciente con carcinoma de mama (CM) y el riesgo de metástasis en el ganglio centinela (GC) y dentro de cada uno de esos grupos el riesgo según el estado de los receptores de estrógeno (RE). Método. Análisis de la base de datos de GC con 1.388 pacientes. Se estudiaron tres grupos de edad: A) posmenopáusicas ancianas, 200 pacientes, ≥70 años; B) posmenopáusicas más jóvenes, 89 pacientes, 5569 años, y C) premenopáusicas, 85 pacientes, <55 años. En cada grupo se analizaron 2 subgrupos: tumores con RE positivos o negativos. Factores estudiados en cada grupo y subgrupo: pacientes con GC positivo, pacientes con ganglios no centinela (GNC) positivos, número de no detecciones quirúrgicas (NDQ) y pacientes no libres de enfermedad (NLE) tras 52 meses de seguimiento. Análisis estadístico: test de chi-cuadrado; significancia p<=0,05. Resultados. En las premenopáusicas el número de GC positivos es significativamente (p<0,025) mayor que en las posmenopáusicas y dentro de las premenopáusicas fundamentalmente en los tumores con RE negativos. El número de GNC positivos aumenta solo discretamente en las premenopáusicas y ocurre exclusivamente en tumores con RE negativos. El número de pacientes NLE es similar en los 3 grupos y en todos ellos es mucho más frecuente en pacientes con tumores con RE negativos. Conclusiones. El número de pacientes con GC positivo varía significativamente con el estado hormonal y no con la edad de la paciente, siendo más frecuentes en las premenopáusicas y fundamentalmente en tumores con RE negativos(AU)
Objective. The influence of the relationship between pre- and post-menopausal stage of patients with breast cancer (BC) and the risk of sentinel lymph node (SLN) metastasis as well as the influence of oestrogen receptor (ER) status within each one of these groups were analyzed. Methods. A BC database with 1,388 patients was analysed. Three age groups were studied: A, elderly postmenopausal, 200 patients, ≥70 years old; B, younger postmenopausal, 89 patients, 5569 years old; C, premenopausal, 85 patients, <55 years old. In each group 2 subgroups were analyzed: positive ER and negative ER tumours. Data analysed: SLN-positive patients, non-sentinel node (NSN)-positive patients, non-surgical detections (NSD) and non disease-free (NDF) patients after a follow-up of 52 months. Statistical analysis: chi-squared test, significance: P<=0.05. Results. SLN metastasis was significantly (P<0.025) more common in premenopausal than in postmenopausal patients, and within those, mainly in negative ER tumours. Positive-NSN increases slightly in premenopausal patients (exclusively in negative ER tumours). NDF patients are similar in the 3 groups and in all of them it is much more frequent in negative ER tumours. Conclusion. SLN metastasis varies significantly according to hormonal state and not according to age, being more frequent in premenopausal patients and mainly in ER negative tumours(AU)
Subject(s)
Humans , Male , Female , Middle Aged , Neoplasm Metastasis/physiopathology , Sentinel Lymph Node Biopsy/methods , Breast Neoplasms/complications , Breast Neoplasms/pathology , Selective Estrogen Receptor Modulators/therapeutic use , Lymph Node Excision/methods , Lymph Node Excision , Carcinoma/complications , Carcinoma/physiopathology , 28599ABSTRACT
OBJECTIVE: The influence of the relationship between pre- and post-menopausal stage of patients with breast cancer (BC) and the risk of sentinel lymph node (SLN) metastasis as well as the influence of oestrogen receptor (ER) status within each one of these groups were analyzed. METHODS: A BC database with 1,388 patients was analysed. Three age groups were studied: A, elderly postmenopausal, 200 patients, ≥ 70 years old; B, younger postmenopausal, 89 patients, 55-69 years old; C, premenopausal, 85 patients, <55 years old. In each group 2 subgroups were analyzed: positive ER and negative ER tumours. Data analysed: SLN-positive patients, non-sentinel node (NSN)-positive patients, non-surgical detections (NSD) and non disease-free (NDF) patients after a follow-up of 52 months. STATISTICAL ANALYSIS: chi-squared test, significance: P ≤ 0.05. RESULTS: SLN metastasis was significantly (P<0.025) more common in premenopausal than in postmenopausal patients, and within those, mainly in negative ER tumours. Positive-NSN increases slightly in premenopausal patients (exclusively in negative ER tumours). NDF patients are similar in the 3 groups and in all of them it is much more frequent in negative ER tumours. CONCLUSION: SLN metastasis varies significantly according to hormonal state and not according to age, being more frequent in premenopausal patients and mainly in ER negative tumours.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/secondary , Estrogens , Lymphatic Metastasis , Neoplasm Proteins/analysis , Neoplasms, Hormone-Dependent/pathology , Receptors, Estrogen/analysis , Sentinel Lymph Node Biopsy , Aged , Aged, 80 and over , Breast Neoplasms/chemistry , Breast Neoplasms/epidemiology , Carcinoma, Ductal, Breast/chemistry , Carcinoma, Ductal, Breast/epidemiology , Carcinoma, Ductal, Breast/pathology , Female , Humans , Middle Aged , Neoplasms, Hormone-Dependent/chemistry , Neoplasms, Hormone-Dependent/epidemiology , Postmenopause , Premenopause , Prevalence , Retrospective Studies , RiskABSTRACT
ObjetivoAnalizar la presencia de ansiedad en pacientes derivados a un servicio de Medicina Nuclear (SMN).Material y métodoSe incluyeron 148 pacientes; 67 derivados para tratamiento con radioyodo, 48 con hipertiroidismo (HT), 19 con carcinoma diferenciado de tiroides (CDT) y 81 para detección y biopsia del ganglio centinela (GC) en carcinoma de mama (CM).Material y métodoSe rellenaron los siguientes documentos: datos de filiación, escala de ansiedad estado-rasgo, escala de factores predisponentes ansiógenos y cuestionario de información.Material y métodoSe estudiaron los factores predisponentes ansiógenos y la influencia de la información en el padecimiento de ansiedad.ResultadosUn 47% de los pacientes con HT tenían ansiedad en el momento de la visita, que no se relacionó con el nivel de información recibido. El factor que más les preocupaba era la administración de radioyodo. El hecho de ser la primera visita a un SMN se relacionó estadísticamente (p<0,05) con la aparición de ansiedad.ResultadosEl 42% de los pacientes con CDT tenían ansiedad en el momento de la visita, que no se relacionó con el nivel de información recibido. El factor que más les preocupaba era la propia enfermedad. Ningún factor fue relacionado estadísticamente con la aparición de ansiedad.ResultadosEl 53% de los pacientes con CM tenían ansiedad en el momento de la visita, que no se relacionó con el nivel de información recibido. El factor que más les preocupaba eran los resultados. El antecedente ansioso-depresivo se relacionó estadísticamente (p<0,05) con la aparición de ansiedad.ConclusiónLa cantidad de información proporcionada antes de un procedimiento en un SMN no influye en el padecimiento de ansiedad. No obstante, es nuestro deber dar la mejor información posible(AU)
ObjectiveTo analyze the presence of anxiety in patients referred to a Nuclear Medicine Department (NMD).Material and methodsA total of 148 patients were included: 67 were referred for radioiodine therapy, 48 with hyperthyroidism (HT), 19 with differentiated thyroid carcinoma (DTC), and 81 were referred for detection and biopsy of the sentinel node in breast cancer (BC).Material and methodsThe following documents were filled out: personal data, a state-trait anxiety inventory, a scale of pre-disposing factors causing anxiety and an information questionnaire.Material and methodsAnxiety-predisposing factors and the influence of the information on the presence of anxiety were studied.ResultsHT patients: 47% had anxiety in the moment of the visit that was not related to the level of information received. The factor that worried them the most was the radioiodine administration. Being the first visit to a NMD significantly influenced (p<0.05) on the presence of anxiety.ResultsDTC patients: 42% had anxiety in the moment of the visit not related to the level of information received. The factor that worried them the most was the illness itself. No factor had a significant influence on the presence of anxiety.ResultsBC patients: 53% had anxiety in the moment of the visit that was not related to the level of information received. What worried them the most were the results. Having anxiety and/or depression significantly influenced (p<0.05) the presence of anxiety.ConclusionThe quantity of information given before a procedure in a NMD does not influence on the presence of anxiety. Nevertheless, it is our duty to give the best possible information(AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Anxiety/psychology , Test Anxiety Scale , Nuclear Medicine/methods , Iodine , Iodine Isotopes , Hyperthyroidism/diagnosis , Thyroid Function Tests/methods , Socioeconomic Survey , Surveys and Questionnaires , Patient SatisfactionABSTRACT
OBJECTIVE: To analyze the presence of anxiety in patients referred to a Nuclear Medicine Department (NMD). MATERIAL AND METHODS: A total of 148 patients were included: 67 were referred for radioiodine therapy, 48 with hyperthyroidism (HT), 19 with differentiated thyroid carcinoma (DTC), and 81 were referred for detection and biopsy of the sentinel node in breast cancer (BC). The following documents were filled out: personal data, a state-trait anxiety inventory, a scale of pre-disposing factors causing anxiety and an information questionnaire. Anxiety-predisposing factors and the influence of the information on the presence of anxiety were studied. RESULTS: HT patients: 47% had anxiety in the moment of the visit that was not related to the level of information received. The factor that worried them the most was the radioiodine administration. Being the first visit to a NMD significantly influenced (p<0.05) on the presence of anxiety. DTC patients: 42% had anxiety in the moment of the visit not related to the level of information received. The factor that worried them the most was the illness itself. No factor had a significant influence on the presence of anxiety. BC patients: 53% had anxiety in the moment of the visit that was not related to the level of information received. What worried them the most were the results. Having anxiety and/or depression significantly influenced (p<0.05) the presence of anxiety. CONCLUSION: The quantity of information given before a procedure in a NMD does not influence on the presence of anxiety. Nevertheless, it is our duty to give the best possible information.
