1.
N Engl J Med
; 370(15): e25, 2014 Apr 10.
Article
in English
| MEDLINE
| ID: mdl-24716703
Subject(s)
AIDS-Related Opportunistic Infections/diagnosis , HIV Infections/diagnosis , HIV-1 , Lung/diagnostic imaging , Pneumocystis carinii/isolation & purification , Pneumonia, Pneumocystis/diagnosis , AIDS-Related Opportunistic Infections/complications , AIDS-Related Opportunistic Infections/drug therapy , Aged , Anti-Infective Agents/therapeutic use , Diagnosis, Differential , Dyspnea/etiology , Female , Fever/etiology , HIV Infections/complications , Humans , Lung/pathology , Oxygen/blood , Pneumonia, Pneumocystis/drug therapy , Pneumonia, Pneumocystis/microbiology , Radiography , Sweating , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
2.
J Virol
; 83(13): 6941-6, 2009 Jul.
Article
in English
| MEDLINE
| ID: mdl-19386719
ABSTRACT
Elite controllers or suppressors (ES) are human immunodeficiency virus type 1 (HIV-1)-infected patients who control viral replication to <50 copies/ml without antiretroviral therapy. Downregulation of HLA class I molecules is an important mechanism used by HIV-1 to evade the immune system. In this study, we showed that primary isolates from ES are as effective as isolates obtained from patients with progressive HIV-1 disease at downregulating HLA-A*2 and HLA-B*57 molecules on primary CD4(+) T cells. Thus, a diminished ability of viral isolates from ES to evade HIV-specific immune responses probably does not contribute to the control of viral replication in these patients.