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Mycoses ; 57(10): 639-43, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24980291

ABSTRACT

Cryptococcus gattii, a species belonging to the Cryptococcus complex which occurs endemically in tropical and subtropical regions, has been reported as a causative agent of cryptococcosis in healthy individuals. We report a case of meningitis in HIV-negative patient from Cuiaba, MT, in the Midwestern region of Brazil. Cryptococcus gattii AFLP6/VGII was isolated from cerebrospinal fluid and molecular typing was performed by URA5-RFLP. The in vitro susceptibility profile was determined using the standard method according to the document M27A3, CLSI 2008. C. gattii AFLP6/VGII was shown to be susceptible to the antifungals tested. Treatment with 0.8 mg/kg of amphotericin B was initiated; however, the patient died 2 days after the onset of therapy.


Subject(s)
Cryptococcosis/microbiology , Cryptococcus gattii/isolation & purification , Meningitis/microbiology , Adult , Antifungal Agents/therapeutic use , Brazil , Child , Child, Preschool , Cryptococcosis/drug therapy , Cryptococcus gattii/drug effects , Cryptococcus gattii/genetics , Fatal Outcome , Female , Genotype , Humans , Male , Meningitis/drug therapy , Middle Aged , Polymorphism, Restriction Fragment Length
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