ABSTRACT
High-grade glial tumors (also called high-grade gliomas) are the most aggressive primary brain neoplasms. Therefore, much attention is paid to understanding the pathogenesis, as well as to the development of new effective diagnostic and therapeutic methods. MicroRNAs are short non-coding RNAs, 18-22 nucleotides in length, which, as has already been shown, play a direct role in carcinogenesis. Circulating miRNAs are released into the extracellular space and can be in a stable state for a long time in most biological liquids, including blood serum and plasma. Circulating miRNAs are promising biomarkers with different expression profiles specific for various human disorders, including cancer diseases.There are many data showing that different profiles of circulating miRNAs, in particular in extracellular vesicles (EV), in human biological fluids are associated with numerous neoplastic processes, which indicates that miRNAs can be a truly new class of biomarkers for early diagnosis and prognosis of high-grade gliomas.
