[Aortic intramural hematoma after transpedicular thoracic spine fusion]. / Intramural'naia gematoma aorty posle transpedikuliarnoi fiksatsii grudnogo otdela pozvonochnika.

A 55-year-old patient M. with compression fractures of Th7-Th8 underwent Th7-Th8 decompressive laminectomy, Th6-Th9 transpedicular spine fusion procedure on January 31, 2017. After that, multiple myeloma was diagnosed at the National Research Center for Hematology. Computed tomography revealed misplacement of a left Th6 screw, its anterior cortical perforation and penetration into the aorta. Signs of intramural hematoma were noticed in this area. The patient was referred to the Petrovsky National Research Center of Surgery. Two-stage surgical approach was preferred. Endovascular repair of the thoracic aorta (TEVAR) was followed by revision of transpedicular fusion system and reinstallation of the screw. Operation was performed on July 14, 2017. Postoperative period was uneventful.

Positive feedback loops for factor V and factor VII activation supply sensitivity to local surface tissue factor density during blood coagulation.

Blood coagulation is triggered not only by surface tissue factor (TF) density but also by surface TF distribution. We investigated recognition of surface TF distribution patterns during blood coagulation and identified the underlying molecular mechanisms. For these investigations, we employed 1), an in vitro reaction-diffusion experimental model of coagulation; and 2), numerical simulations using a mathematical model of coagulation in a three-dimensional space. When TF was uniformly immobilized over the activating surface, the clotting initiation time in normal plasma increased from 4 min to >120 min, with a decrease in TF density from 100 to 0.7 pmol/m(2). In contrast, surface-immobilized fibroblasts initiated clotting within 3-7 min, independently of fibroblast quantity and despite a change in average surface TF density from 0.5 to 130 pmol/m(2). Experiments using factor V-, VII-, and VIII-deficient plasma and computer simulations demonstrated that different responses to these two TF distributions are caused by two positive feedback loops in the blood coagulation network: activation of the TF-VII complex by factor Xa, and activation of factor V by thrombin. This finding suggests a new role for these reactions: to supply sensitivity to local TF density during blood coagulation.

[Muscle glycoproteins (soluble in perchloric acid) after denervation and drug stimulation]. / Glikoproteidy myshts (rastvorimye v khlornoi kislote) posle denervatisii i medikamentoznoi stimuliatsii.

Muscle proteins soluble in perchloric acid contain about 75% of carbohydrates presented by neutral hexoses, fucose and hexuronic acids. Three days and two weeks after denervation the content of the glycoproteids protein part is unchanged, a month later it increases by 116%. The content of carbohydrate component following denervation lowers considerably and a month later is on the average 40% higher than in the muscle of healthy rats. Administration of muscular RNA restores the content of the protein component only by the end of a month; administration of pyrogenal normalizes the content of both protein and carbohydrate components.

[Changes in the protein content and their amino acid makeup in the muscles in feeding rats corn with an increased lysine content]. / Zminy vmistu bilkiv ta ikh aminokyslotnoho skladu u m'iazakh pry hodivli shchuriv kukurudzoiu z pidvyshchenym vmistom lizynu

The biochemical indexes of the rat muscles were studied as affected by maize with a higher content of lysin. It is shown that a month after an increase in the body weight and mass of muscles are more pronounced in the rats which were fed maize with a higher content of lysin. The latter, evidently, is due to an increase in the content of sarcoplasmatic proteins, RNA, as well as macroergic compounds, ATP and creatine phosphate, in the muscle of the animals under experiment. The qualitive composition of muscles proteins changes in these animals. A rated gain in essential amino acids is observed as compared to the control group. Hence the feeding of the maize with a higher content of lysin to animals may increase the feed value of meat products.