[Parameters of cellular immunity in lung cancer patients with different types of adaptation reactions during polychemotherapy]. / Pokazateli kletochnogo immuniteta u bol'nykh rakom lëgkogo s razlichnymi tipami adaptatsionnykh reaktsii v protzesse provedeniia polikhimioterapii.

A relationship between cellular immunity and general adaptation syndrome in the course of CAM polychemotherapy has been investigated. The results point to a lack of lymphopenia, lower levels of T-suppressors and higher instability of immunological indices in patients showing increased activation reaction and maximum antitumor resistance during cytostatic therapy, unlike in those in stress. This opens an opportunity for correction.

[The possible glyciram stimulation of bone marrow hematopoiesis under cytostatic blood depression]. / O vozmozhnosti stimuliatsii glitsiramom kostnomozgovogo krovetvoreniia v usloviiakh tsitostaticheskoi gemodepressii.

The present study was undertaken to examine whether glycyrram orally given can correct blood abnormalities caused by a single maximal tolerable dose of fluorouracil. Glycyrram was demonstrated to stimulate the recovery of granulocytic and erythroid populations of bone marrow hemopoiesis. The stimulating effect of glycyrram was associated with its activating action on the function of hemopoietic microenvironmental cells.

[The principles for creating drug preparations of natural origin that stimulate hematopoiesis]. / Printsipy sozdaniia lekarstvennykh preparatov--stimuliatorov krovetvoreniia prirodnogo proiskhozhdeniia.

The paper outlines the principles in designing hemostimulators by using glycosamineglycans. Hemostimulating properties of the tested agents is likely to be primarily due to the presence of D-glucuronic acid in their structure. The homotypic mechanisms are largely responsible for all agents' effect in stimulating hemopoiesis. Thus, they all virtually activate the function of the hemopoiesis-inducing microenvironment. In addition, they directly or indirectly stimulate the processes of proliferation and differentiation of precursor cells of erythro- and granulomonocytopoiesis.

[The dynamics of laboratory indices during the treatment of chronic alcoholism]. / Dinamika laboratornykh pokazatelei pri lechenii khronicheskogo alkogolizma.

Some hematological and biochemical parameters and the body nonspecific reactivity have been examined in 57 patients with Stage II chronic alcoholism (CA) during the first, fourth, and seventh weeks of abstinence from alcohol. The serum iron level has been within the normal range, though a tendency to hyperferremia has manifested during the 4th week of abstinence. Transaminases have been elevated on week 1 and normalized by week 4, thus remaining by week 7. The red cell volume is increased in chronic alcoholics; it persists so through the course of treatment, though showing a tendency to normalization after 7 weeks of abstinence from alcohol. This sign is rather stable and persists for up to 4 weeks after alcohol is discontinued. Examination of the nonspecific reactivity has shown a reduced neutrophilic phagocytic activity and a lowered content of IgM, parallelled by a rise of the IgA content. The nonspecific resistance factors show a tendency to normalization by the 7th week of abstinence, except the IgM level. The maximum deviations from the norm are observed on week 4 of alcohol abstinence, as regards the majority of the parameters.