ABSTRACT
AIM: To estimate the late duration of the effect of 3-week intravenous alpha-lipoic acid (alpha-LA) administration. SUBJECTS AND METHODS: The study included patients with symptoms of myodiabetic polyneuropathy. The authors studied trends in neuropathic symptoms by the TSS scale and neuropathic deficit by the NIS-LL scale after 3-week intravenous alpha-LA (600 mg/day) administration. Control follow-up visits were made at weeks 8 and 30 of the study. RESULTS: In alpha-LA-treated patients, the mean TSS score dropped from 9.46 +/- 1.01 to 3.29 +/- 1.49 after intravenous alpha-LA administration and continued to decrease to 260 +/- 1.18 and 4.39 +/- 201 scores at follow-up weeks 8 and 30, respectively. In the placebo group, these were 9.78 +/- 1.23, 6.16 +/- 1.95, 6.52 +/- 1.61, and 736 +/- 1.31 scores at weeks 3, 8, and 30, respectively; p < 0.05). In the alpha-LA group, NIS-LL scores fell from 8.65 +/- 3.46 to 6.01 +/- 3.12 at therapy week 3, to 6.11 +/- 3.36, at week 8, and to 7.68 +/- 3.68 at week 30 and in the placebo group, these decreased from 8.35 +/- 3.84 to 7.81 +/- 3.51, 7.89 +/- 3.72, and 8.32 +/- 3.49 scores at weeks 3, and 8, respectively; p < 0.05). CONCLUSION: . Alleviated neuropathic symptoms persisted within 6 months after 3-week intravenous alpha-LA injection. Reduced neuropathic deficit did within 8 weeks after initiation of alpha-LA therapy.
Subject(s)
Antioxidants/administration & dosage , Diabetic Neuropathies/drug therapy , Thioctic Acid/administration & dosage , Double-Blind Method , Drug Administration Schedule , Female , Follow-Up Studies , Humans , Injections, Intravenous , Male , Middle Aged , Time Factors , Treatment OutcomeSubject(s)
Central Nervous System Diseases/diagnosis , Magnetoencephalography , Peripheral Nervous System Diseases/diagnosis , Adolescent , Adult , Aged , Amyotrophic Lateral Sclerosis/diagnosis , Demyelinating Diseases/diagnosis , Humans , Magnetics , Middle Aged , Multiple Sclerosis/diagnosis , Muscles/physiology , Muscles/physiopathology , Physical StimulationABSTRACT
Magnetic stimulation of the cerebral cortex and roots CVI--CVII and LII--LIV was performed in 19 healthy subjects, 45 multiple sclerosis (MS), 21 lateral amyotrophic sclerosis and 24 demyelinating polyneuropathy patients. M-response of m. abductor digiti min (AdV) and m. tibialis ant. (TA) was registered. The difference of M-response latent time induced by the stimulation, CVI--CVII and LII--LIV determined the time of the impulse central conduction (ICC) to the corresponding roots. In healthy subjects ICC--C amounts to 8.28 +/- 1 ms (maximum 10.3 ms), ICC--S is equal to 14.6 +/- 1.46 ms (maximum 16.8 ms). In patients with the above affections increased ICC was a frequent finding which also occurred in subclinical pyramidal lesions.
