Subject(s)
Bronchiectasis/diagnosis , Common Variable Immunodeficiency/diagnosis , Gastritis, Atrophic/diagnosis , Vitiligo/diagnosis , Bronchiectasis/pathology , Chronic Disease , Common Variable Immunodeficiency/pathology , Diagnosis, Differential , Female , Gastric Mucosa/pathology , Gastritis, Atrophic/pathology , Humans , Intestinal Mucosa/pathology , Middle Aged , Vitiligo/pathologyABSTRACT
We investigated whether emulsification glaucoma after silicone oil implantation can be influenced positively by removal of the oil. In 16 of 264 patients successfully operated upon with purified silicone oil 5000 cps, we found a glaucoma refractory to medical therapy and probably caused by emulsification. We removed the silicone oil from these eyes and followed them up for a period of 6 months (12.5 +/- 7.3 months). In 12 of the 16 eyes, the intraocular pressures were normalized after silicone oil removal with or without antiglaucomatous therapy. Four eyes showed raised intraocular pressures in spite of silicone oil removal. These could, however, be largely explained by neovascularization or chronic inflammation with increasing anterior synechia formation. In eyes with possible emulsification glaucoma, early and thorough removal of the silicone oil is therefore recommended since this can result in normalization of intraocular pressures in a large percentage of cases.
Subject(s)
Glaucoma/chemically induced , Postoperative Complications/chemically induced , Silicone Oils/adverse effects , Vitrectomy , Glaucoma/surgery , Humans , Intraocular Pressure/drug effects , Postoperative Complications/surgery , Reoperation , Silicone Oils/administration & dosageABSTRACT
Engymetry offers a new means of continuously measuring nuclear radiation fields without any need of restricting the patient's mobility. In this study, kidney function was measured simultaneously and continuously for 6.6 h with engymetry, after application of a 12 h therapy dose of Cyclosporine A (CsA) of 4.0 +/- 1.8 mg per kg bodyweight (bw). 15 kidney transplanted patients participated in this study. 370 MBq 99Tcm-DTPA and 10 MBq 131I-OIH were injected during routine transplant scintigraphy. Renal function was monitored from the external disappearance curves of the tracers recorded by portable double radionuclide detectors. Renal impairment could be seen in the rising phase of CsA or coincided with the CsA maximum in 13 of the 15 patients. Under the impairment the half-life of 99Tcm-DTPA increased from 4.1 +/- 1.2 to 15.9 +/- 12.3 h (p less than 0.005) for 61 +/- 45 min and the half-life of 131I-OIH increased from 3.2 +/- 0.7 to 12.7 +/- 8.4 h (p less than 0.001) for 71 +/- 37 min. With noninvasive engymetry it is possible to detect renal functional impairment during long observation periods. Acute restriction in glomerular filtration and renal blood flow was discovered in human kidney graft recipients after the application of a low therapeutic CsA dose.
Subject(s)
Acute Kidney Injury/diagnostic imaging , Cyclosporins/adverse effects , Iodine Radioisotopes , Kidney Transplantation , Nuclear Medicine/instrumentation , Organometallic Compounds , Pentetic Acid , Acute Kidney Injury/chemically induced , Acute Kidney Injury/physiopathology , Adult , Aged , Cyclosporins/administration & dosage , Cyclosporins/pharmacology , Evaluation Studies as Topic , Female , Glomerular Filtration Rate/drug effects , Half-Life , Humans , Infusions, Intravenous , Male , Middle Aged , Monitoring, Physiologic , Radionuclide Imaging , Renal Circulation/drug effects , Technetium Tc 99m PentetateABSTRACT
Six women with long-standing functional amenorrhoea were treated with 5 microgram of D-Ser (TBU)6 LH-RH-EA twice daily for 14 days. The functional states of the gonadostats, as assessed by a 25 microgram LH-RH test dose, varied widely before the treatment was started whereas at the end of it they were uniformly low. In all patients D-Ser (TBU)6 LH-RH-EA induced gonadotrophin release, the peak values occuring between day 1 and 3 of therapy. Despite further injections mean gonadotrophin levels declined rapidly therafter and remained in the basal range for the rest of the study. Release of oestradiol was very uncharacteristic. No consistent ovarian response pattern was observed during the analogue administration. It is obvious that chronic stimulation with D-Ser (TBU)6 LH-RH-EA leads to a decreased responsiveness of the pituitary gland.
