Stereoselective total synthesis of Aspergillide D.

The total synthesis of the 16-membered Polyhydroxylated macrolide, Aspergillide D has been accomplished utilizing the Grignard reaction, Sharpless asymmetric epoxidation Regioselective ring opening of epoxy alcohol, Wittig olefination and Yamaguchi macrolactonisation as key steps. 3-butene-1-ol has been utilized as the starting material.

Understanding the endocrine disruptor and determination of bisphenol A by functional Cu-BTABB-MOF/rGO composite as facile rapid electrochemical sensor: an experimental and DFT investigation.

A pioneering CuBTABB-MOF/rGO composite customized electrode is fabricated and utilized as a sensor towards identifying bisphenol A (BPA) in a phosphate buffer solution of pH 7.0. The composite is characterized by FTIR, Raman spectroscopy, XRD, SEM, EDX, HRTEM, and XPS to study its structural and morphological properties. Compared with Cu-BTABB-MOF and Cu-BTABB-MOF@GO, the Cu-BTABB-MOF@rGO modified electrode is more sensitive and selective to BPA due to a strong interaction between them. The developed Cu-BTABB-MOF@rGO modified electrode exhibits good sensitivity (6.95 × 10-5 A mol-1 L-1) for BPA having a wide linear range of 0-100 µmol L-1 with the LOD of 2.08 × 10-5 mol L-1, reproducibility of 4.35%, and relative standard deviation (RSD) and stability of 90% for thirty days. In addition, the developed electrocatalyst remained unoccupied from interfering substances and consequently provided an encouraging platform for swift detection of BPA in real samples such as pond water and packed water bottles. Additionally, we utilized DFT (density functional theory) to model GO and Cu-BTABB-MOF structures for detecting BPA molecules.

Review on recent progress in metal-organic framework-based materials for fabricating electrochemical glucose sensors.

Diabetes is a type of disease that threatens human health, which can be diagnosed based on the level of glucose in the blood. Recently, various MOF-based materials have been developed as efficient electrochemical glucose sensors because of their tunable pore channels, large specific surface area well dispersed metallic active sites, etc. In this review, the significance of glucose detection and the advantages of MOF-based materials for this application are primarily discussed. Then, the application of MOF-based materials can be categorized into two types of glucose sensors: enzymatic biosensors and non-enzymatic sensors. Finally, insights into the current research challenges and future breakthrough possibilities regarding electrochemical glucose sensors are considered.

Improved performance of lithium-sulfur batteries by employing a sulfonated carbon nanoparticle-modified glass fiber separator.

Some of the most promising alternatives in the energy storage sector are lithium-sulfur batteries, which have a high energy density and theoretical capacity. However, the low electrical conductivity of sulfur and the shuttle effect of polysulfides remain important technical obstacles in the practical use of lithium-sulfur batteries (LSBs). This work employed a glass fiber separator with sulfonated carbon nanoparticles (SCNPs) to reduce the shuttle effect. The negatively charged sulfonic groups in SCNPs might prevent polysulfide migration and anchor lithium polysulfides. By using carbon-based interlayers, this method improves ion conductivity. Furthermore, the equally scattered sulfonic groups serve as active sites, causing sulfur to be distributed consistently and limiting sulfur growth while enhancing active sulfur utilization. After 200 cycles at 1C, the SCNP separator-containing cell showed a specific capacity of 1080 mA h g-1. After 200 cycles, the cell with a CNP separator only showed a specific capacity of 854 mA h g-1, demonstrating that CNPs' polysulfide diffusion suppression was ineffective. The cell with the SCNP separator still showed a high capacity of 901 mA h g-1 after 500 cycles, with an average coulombic efficiency of almost 98%.

Development and validation of a gas chromatography method for the trace level determination of allylamine in sevelamer hydrochloride and sevelamer carbonate drug substances.

A capillary gas chromatography method using a flame ionization detector has been developed for the trace analysis of allylamine (AA) in sevelamer hydrochloride (SVH) and sevelamer carbonate (SVC) drug substances. The method utilized a mega bore capillary column DB-CAM (30 m × 0.53 mm × 1.0 µm) with a bonded and cross-linked, base-deactivated polyethylene glycol stationary phase and was validated for specificity, sensitivity, precision, linearity, and accuracy. The detection and quantitation limits obtained for allylamine were 2 µg/g and 6 µg/g, respectively. The method was found to be linear in the range between 6 µg/g and 148 µg/g with a correlation coefficient of 0.9990. The average recoveries obtained in SVH and SVC were 93.9% and 99.1%, respectively. The developed method was found to be robust for the determination of AA in sevelamer drug substances and also the specificity was demonstrated with a gas chromatograph coupled with a mass spectrometer.