Subject(s)
Humans , Male , Female , Pregnancy , Adolescent , Pregnancy in Adolescence , Adolescent Mothers , Adolescent FathersABSTRACT
A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the safety, reactogenicity and the immunogenicity of a 2 x 10(9)CFU dose of the 638 lyophilized live attenuated cholera vaccine for oral administration, formulated and produced at Finlay Institute, City of Havana, Cuba. Thirty-six healthy female and male adult volunteers from 18 to 40 years old were involved, clinically examined and laboratory tested after the informed consent signature. Adverse events were monitored and seroconversion rates and geometrical mean titer (GMT) of vibriocidal antibodies were tested in volunteer's sera samples. Neither serious adverse events nor other damages to the volunteers due to vaccine or placebo feeding were reported during the clinical follow-up period of this study; none of the adverse events registered within the first 72 h after inoculation were life-threatening for volunteers. Neither severe nor moderate adverse events were reported. Sixty-one percent of subjects showed mild expected adverse events in an interval lower than 24h up to the first 72 h, 75% of these in the vaccinated group and 18% in the placebo group. Fourteen days after inoculation the GMT of vibriocidal antibodies in the vaccine group significantly increased in comparison to the placebo group. All subjects in the vaccine group (24) seroconverted (100%). Results show that this vaccine is safe, well tolerated and immunogenic in healthy female and male volunteers.
Subject(s)
Cholera Vaccines/administration & dosage , Cholera/prevention & control , Administration, Oral , Adolescent , Adult , Antibodies, Bacterial/blood , Cholera/immunology , Cholera Vaccines/adverse effects , Cholera Vaccines/immunology , Cuba , Double-Blind Method , Female , Humans , Male , Vaccines, Attenuated/administration & dosage , Vaccines, Attenuated/adverse effects , Vaccines, Attenuated/immunology , Young AdultABSTRACT
Realizamos un estudio descriptivo retrospectivo en el Hospital Francisco Moscoso Puello de Santo Domingo, República Dominicana, desde agosto 1992-1995; valorando una población de 122 casos con traumatismo torácico, tratados mediante eld renaje de sello de agua. La edad más afectada fue de 20-29 años con un 50.8// de los casos. El hemitórax más afectado fue el izquierdo en un 56.6// de los casos. El agente vulnerable más relacionado fue el arma blanca en 91.8// de los casos
