Subject(s)
Androstenes/adverse effects , Desensitization, Immunologic , Drug Hypersensitivity/immunology , Drug Hypersensitivity/therapy , Androstenes/administration & dosage , Biomarkers , Desensitization, Immunologic/adverse effects , Desensitization, Immunologic/methods , Drug Hypersensitivity/diagnosis , Humans , Male , Middle Aged , Skin Tests , Time Factors , Treatment OutcomeSubject(s)
Hymenoptera/immunology , Hypersensitivity/diagnosis , Hypersensitivity/immunology , Mastocytosis/diagnosis , Mastocytosis/immunology , Venoms/immunology , Adult , Allergens/immunology , Animals , Cross Reactions/immunology , Humans , Hypersensitivity/drug therapy , Immunization , Immunoglobulin E/blood , Immunoglobulin E/immunology , Insect Bites and Stings/immunology , Male , Mastocytosis/drug therapy , Omalizumab/administration & dosage , Skin TestsABSTRACT
BACKGROUND AND OBJECTIVE: Allergen immunotherapy clinics (AITCs) in Spain differ widely in terms of structure, organization, resources, and portfolio of services. Therefore, it is essential to unify treatment criteria and define quality standards for the most complex AITCs. Objective: To establish a series of recommendations that make it possible to guarantee quality and safety in the administration of immunotherapy and define quality standards for the most complex AITCs. METHODS: This project began with an online survey of 65 allergy departments/units throughout Spain in 2013. Next, a 2-phase consensus process was carried out. In the first phase, 10 experts defined and agreed on the standards using the RAND/UCLA Appropriateness method; in the second, the agreements were validated by means of a 2-round Delphi consultation with 84 experts. RESULTS: Consensus was reached on minimum safety and quality criteria in the administration of allergen immunotherapy, and 2 levels of highly complex AITCs were defined: accredited AITCs and accredited AITCs with excellence. Consensus was also reached on quality standards and accreditation criteria for both levels. CONCLUSIONS: This project is pioneering in terms of its purpose (the definition of quality standards for AITCs) and of the use of structured participation techniques (combination of the RAND/UCLA and Delphi methods). It enabled the design of minimum standards for quality and safety in administering AIT, as well as quality criteria for accreditation of AITCs supported by a broad panel of experts from the Spanish Society of Allergology and Clinical Immunology.
Subject(s)
Desensitization, Immunologic , Hypersensitivity/epidemiology , Hypersensitivity/therapy , Quality of Health Care , Consensus , Desensitization, Immunologic/methods , Desensitization, Immunologic/standards , Expert Testimony , Humans , Hypersensitivity/immunology , Internet , Public Health Surveillance , Quality Indicators, Health Care , Referral and Consultation , Spain/epidemiology , Surveys and QuestionnairesABSTRACT
BACKGROUND: Allergen immunotherapy clinics (AITCs) in Spain differ widely in terms of structure, organization, resources, and portfolio of services. Therefore, it is essential to unify treatment criteria and define quality standards for the most complex AITCs. OBJECTIVE: To establish a series of recommendations that make it possible to guarantee quality and safety in the administration of immunotherapy and define quality standards for the most complex AITCs. METHODS: This project began with an online survey of 65 allergy departments/units throughout Spain in 2013. Next, a 2-phase consensus process was carried out. In the first phase, 10 experts defined and agreed on the standards using the RAND/UCLA Appropriateness method; in the second, the agreements were validated by means of a 2-round Delphi consultation with 84 experts. RESULTS: Consensus was reached on minimum safety and quality criteria in the administration of allergen immunotherapy, and 2 levels of highly complex AITCs were defined: accredited AITCs and accredited AITCs with excellence. Consensus was also reached on quality standards and accreditation criteria for both levels. CONCLUSIONS: This project is pioneering in terms of its purpose (the definition of quality standards for AITCs) and of the use of structured participation techniques (combination of the RAND/UCLA and Delphi methods). It enabled the design of minimum standards for quality and safety in administering AIT, as well as quality criteria for accreditation of AITCs supported by a broad panel of experts from the Spanish Society of Allergology and Clinical Immunology
ANTECEDENTES: Las unidades de inmunoterapia (UIT) en España son muy diferentes en cuanto a estructura, organización, recursos y cartera de servicios. Por ello, resulta esencial homogeneizar criterios de actuación y definir estándares de calidad para las UIT de mayor complejidad. OBJETIVO: Establecer recomendaciones que permitan garantizar la calidad y seguridad en la administración de la inmunoterapia y definir estándares de calidad para las UIT de mayor complejidad. MÉTODOS: Proyecto iniciado (año 2013) con una encuesta on-line a 65 servicios o unidades de alergología de toda España. Posteriormente, se desarrolló un proceso de consenso en dos fases. En la primera, diez expertos definieron y consensuaron los estándares mediante el método RAND/UCLA; en la segunda, los acuerdos se validaron mediante una consulta Delphi a dos rondas con 84 expertos. RESULTADOS: Se consensuaron criterios mínimos de seguridad y calidad en la administración de inmunoterapia con alérgenos (ITA) y se definieron dos niveles de UIT de mayor complejidad: las UIT acreditadas (UITA) y las UIT acreditadas con excelencia (UITAE), consensuándose también los estándares de calidad y criterios de acreditación para ambos niveles. CONCLUSIONES: Proyecto pionero en su objetivo - definición de estándares de calidad de UIT- y en el empleo de técnicas de participación estructuradas -combinación de los métodos RAND/UCLA y Delphi-. El resultado es la definición de unos mínimos de calidad y seguridad para administrar ITA, y un conjunto de criterios de calidad para la acreditación de las UIT que cuenta con el respaldo de un amplio panel de expertos de la SEAIC
Subject(s)
Humans , Desensitization, Immunologic , Hypersensitivity/epidemiology , Hypersensitivity/therapy , Quality of Health Care , Consensus , Desensitization, Immunologic/methods , Desensitization, Immunologic/standards , Expert Testimony , Hypersensitivity/immunology , Internet , Public Health Surveillance , Quality Indicators, Health Care , Referral and Consultation , Spain/epidemiology , Surveys and QuestionnairesABSTRACT
No disponible
Subject(s)
Humans , Animals , Male , Adult , Hymenoptera/immunology , Hypersensitivity/diagnosis , Hypersensitivity/immunology , Mastocytosis/diagnosis , Mastocytosis/immunology , Venoms/immunology , Allergens/immunology , Immunization , Immunoglobulin E/blood , Immunoglobulin E/immunology , Insect Bites and Stings/immunology , Cross Reactions/immunology , Hypersensitivity/drug therapy , Mastocytosis/drug therapy , Omalizumab/administration & dosage , Skin TestsABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Androstenes/adverse effects , Desensitization, Immunologic , Drug Hypersensitivity/immunology , Drug Hypersensitivity/therapy , Androstenes/administration & dosage , Time Factors , Treatment Outcome , Biomarkers , Desensitization, Immunologic/adverse effects , Desensitization, Immunologic/methods , Drug Hypersensitivity/diagnosis , Skin TestsABSTRACT
The prevalence of sensitization to dogs and cats varies by country, exposure time and predisposition to atopy. It is estimated that 26% of European adults coming to the clinic for suspected allergy to inhalant allergens are sensitized to cats and 27% to dogs. This document is intended to be a useful tool for clinicians involved in the management of people with dog or cat allergy. It was prepared from a consensus process based on the RAND/UCLA method. Following a literature review, it proposes various recommendations concerning the diagnosis and treatment of these patients, grounded in evidence and clinical experience. The diagnosis of dog and cat allergy is based on a medical history and physical examination that are consistent with each other and is confirmed with positive results on specific IgE skin tests. Sometimes, especially in polysensitized patients, molecular diagnosis is strongly recommended. Although the most advisable measure would be to avoid the animal, this is often impossible and associated with a major emotional impact. Furthermore, indirect exposure to allergens occurs in environments in which animals are not present. Immunotherapy is emerging as a potential solution to this problem, although further supporting studies are needed.
Subject(s)
Allergens/immunology , Hypersensitivity/diagnosis , Hypersensitivity/immunology , Pets/immunology , Algorithms , Animals , Cats , Combined Modality Therapy , Consensus , Disease Susceptibility , Dogs , Hypersensitivity/therapy , Immunization , Immunoglobulin E/immunology , Prevalence , Quality of Life , Skin TestsSubject(s)
Anaphylaxis/chemically induced , Diospyros/adverse effects , Food Hypersensitivity/etiology , Anaphylaxis/blood , Anaphylaxis/diagnosis , Anaphylaxis/drug therapy , Anaphylaxis/immunology , Anti-Allergic Agents/therapeutic use , Biomarkers/blood , Child , Diospyros/immunology , Food Hypersensitivity/blood , Food Hypersensitivity/diagnosis , Food Hypersensitivity/drug therapy , Food Hypersensitivity/immunology , Fruit , Humans , Immunoglobulin E/blood , Intradermal Tests , Male , Predictive Value of Tests , Risk FactorsSubject(s)
Desensitization, Immunologic/methods , Drug Hypersensitivity/prevention & control , Granulocyte Colony-Stimulating Factor/administration & dosage , Granulocyte Colony-Stimulating Factor/adverse effects , Hypersensitivity, Immediate/prevention & control , Neutropenia/drug therapy , Adult , Anti-Allergic Agents/therapeutic use , Antineoplastic Agents/adverse effects , Cross Reactions , Drug Hypersensitivity/diagnosis , Drug Hypersensitivity/etiology , Drug Hypersensitivity/immunology , Female , Filgrastim , Granulocyte Colony-Stimulating Factor/immunology , Humans , Hypersensitivity, Immediate/chemically induced , Hypersensitivity, Immediate/diagnosis , Hypersensitivity, Immediate/immunology , Immune Tolerance , Intradermal Tests , Lenograstim , Neutropenia/chemically induced , Predictive Value of Tests , Recombinant Proteins/administration & dosage , Recombinant Proteins/adverse effects , Recombinant Proteins/immunology , Severity of Illness Index , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Humans , Male , Child , Anaphylaxis/diagnosis , Food Hypersensitivity/diagnosis , Ebenaceae/adverse effects , Rhinitis, Allergic, Seasonal/complications , Skin TestsABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Granulocyte Colony-Stimulating Factor/adverse effects , Drug Hypersensitivity/therapy , Desensitization, Immunologic , Breast Neoplasms/drug therapy , Carcinoma, Ductal, Breast/drug therapyABSTRACT
No disponible
Subject(s)
Adult , Female , Humans , Lipocalin 1/analysis , Serum Albumin/administration & dosage , Serum Albumin/analysis , Allergens/isolation & purification , Molecular Weight , Serum Albumin/isolation & purification , Hypersensitivity/complications , Hypersensitivity/diagnosis , Hedgehogs/immunology , Allergy and Immunology/standards , Allergens/immunology , Hypersensitivity, Immediate/complications , Hypersensitivity, Immediate/diagnosis , Immunoglobulin E/immunology , Immunoglobulin E/isolation & purification , Respiratory Tract Diseases/immunology , Immunoblotting/methods , ImmunoblottingSubject(s)
Angioedema/chemically induced , Desensitization, Immunologic/methods , Drug Hypersensitivity/immunology , Ferric Compounds/administration & dosage , Ferrous Compounds/adverse effects , Sucrose/administration & dosage , Urticaria/chemically induced , Anemia, Iron-Deficiency/drug therapy , Anemia, Iron-Deficiency/immunology , Angioedema/immunology , Female , Ferric Oxide, Saccharated , Ferrous Compounds/administration & dosage , Ferrous Compounds/immunology , Glucaric Acid , Humans , Middle Aged , Urticaria/immunologyABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Iron Compounds/adverse effects , Anemia, Iron-Deficiency/drug therapy , Desensitization, Immunologic , Drug Hypersensitivity/therapy , Urticaria/chemically induced , Angioedema/chemically inducedABSTRACT
A 48-year-old woman developed drug-induced subacute lupus erythematosus while taking lamotrigine. The eruption resolved after discontinuance of lamotrigine, suggesting this drug as the cause.
Subject(s)
Anticonvulsants/adverse effects , Lupus Erythematosus, Cutaneous/chemically induced , Triazines/adverse effects , Drug Eruptions/immunology , Female , Humans , Lamotrigine , Lupus Erythematosus, Cutaneous/immunology , Middle AgedABSTRACT
Antihistamines are widely used drugs. Hypersensitivity reactions with these drugs are rare and a challenge for the physician. We describe 5 outpatients who experienced urticaria after taking antihistamines. All 5 were treated at our outpatient clinic over a period of 15 years. The allergy workup included a clinical history, skin prick testing, patch testing with antihistamines, and single-blind placebo-controlled oral challenge tests. Biopsy samples were taken and serum tryptase levels were determined in 1 patient. The results of the skin prick tests and patch tests were negative in all patients but 1, in whom the prick test result was positive to some antihistamines. We confirmed all diagnoses using a single-blind challenge test. The biopsy obtained from 1 patient strongly supported urticaria. We present 5 cases of antihistamine-induced urticaria where the immunologic mechanism remains unclear. Hypersensitivity reactions should be taken into account in patients receiving antihistamines, especially in those who experience urticaria.