[Glucose tolerance disorders in patients with hypothyroidism]. / O narusheniiakh tolerantnosti k gliukoze u bol'nykh gipotireozom.

Altogether 42 patients with hypothyrosis of different etiology (aged 17 to 57) were investigated. According to the results of oral glucose tolerance test (OGTT) all the patients were divided into 3 groups: normal OGTT, disturbed OGTT and a flat type of glycemic curves. High levels of cortisol and free fatty acids (FFA) were detected in persons with disturbed OGTT. A lowered reaction to insulin was found in 15 patients with high levels of cortisol and FFA. Persons with unchanged sensitivity to insulin demonstrated a normal type of OGTT and normal blood levels of cortisol and FFA, and among patients with a low reaction to insulin there were persons with disturbed OGTT and high blood levels of cortisol and OGTT. Positive correlation was found between OGTT disturbances, on the one hand, and lowered sensitivity to insulin, increased blood levels of cortisol and FFA, on the other hand. A conclusion has been made that one of the causes of GTT disturbance in patients with hypothyrosis is an increase in the blood levels of cortisol and FFA and a decrease of sensitivity to insulin.

[Suppression of development of autoimmune thyroiditis during prolonged stimulation of T-cellular immunity]. / Supressiia razvitiia éksperimental'nogo autoimmunnogo tireoidita v protsesse dlitel'noi stimuliatsii T-kletochnogo immuniteta.

The purpose of this experiment was to investigate the suppression of autoimmune thyroiditis in guinea-pigs by prolonged stimulation of T-cellular immunity with T-activin, a thymic hormone. The development of experimental autoimmune thyroiditis (EAT) at early stages was shown to be characterized by deficiency of T-cells of helper and suppressor phenotypes, hypersecretion of thyroid hormones and insignificant development of a thyroid autoimmune process. With disease development indices of peripheral blood immunity of guinea-pigs were close to normal, and the frequency and degree of lymphoid infiltration of the gland were increased in parallel with the development of hypofunction of the organ. Immuno-correction of developing EAT with injections of T-activin according to our scheme resulted in a prolonged stimulation of T-cellular immunity, prevented sensitization of lymphocytes with thyroid antigens, increased secretion of the thymic hormones in parallel with a decrease in a degree of lymphoid-plasmacytic infiltration from thyroid tissues, indicating suppression of the disease.

[Dynamics of various indicators of cellular immunity in patients with diffuse toxic goiter after drug therapy]. / Dinamika nekotorykh pokazatelei kletochnogo immuniteta u bol'nykh diffuznym toksicheskim zobom pod vliianiem medikamentoznoi terapii.

The purpose of the investigation was to study some indices of the immune system of patients with diffuse toxic goiter (DTG) before multimodality thyrostatic therapy and after achieving clinical remission. A total of 30 DTG patients with an average severity of disease were examined. The immune status was evaluated according to the content of T-lymphocytes, T-suppressors, Fc gamma-lymphocytes and antigen-binding lymphocytes (ABL) responsive to thyroglobulin. Conservative therapy included mercazolyl, beta-adrenergic blockers, sedative and cardiac drugs. A drop of T1T gamma and Fc gamma-lymphocytes was revealed in the period of the manifestation of the clinical signs of disease. The indices of ABL responsive to thyroglobulin significantly exceeded the relative and absolute indices of the control group. Multimodality drug therapy resulted in the deepening of T-lymphocyte deficiency, a significant rise of T gamma 1 and T gamma 2 as compared to the initial levels. A tendency to a decrease in the level of Fc gamma-lumphocytes was noted after the therapy. The relative and absolute values of the ABL indices significantly decreased, however a significant increase in these indices compared to the control ones maintained.