ABSTRACT
Aim of the study was to assess effect of monotherapy with nebivolol, bisoprolol, carvedilol for 2 months on sexual function in men with arterial hypertension (AH). Men with 1-2 degree of AH (n=75, age 35-55 years, mean age 48+/-3,5 years) received monotherapy with these drugs for 2 months. Registration of parameters of heart rate variability (HRV), Dopplerography of penile arteries, and the Vasilchenko questionnaire were implemented at the end of 4 months of placebo period and after 2 months of therapy with a study drug. Therapy with bisoprolol, carvedilol, and nebivolol was associated with significant elevation of parasympathetic part of vegetative nervous system tone, improvement of systolic blood flow in cavernous and dorsal arteries. Analysis of data obtained by Vasilchenko questionnaire demonstrated improvement of psychic and erectile components of sexual function. Thus bisoprolol, carvedilol, and nebivolol did not worsen sexual function of men with AH, improved spectral parameters of HRV and vascular blood flow in arteries of cavernous bodies.
Subject(s)
Benzopyrans , Bisoprolol , Carbazoles , Erectile Dysfunction , Ethanolamines , Hypertension/drug therapy , Penile Erection/drug effects , Propanolamines , Adult , Antihypertensive Agents/administration & dosage , Antihypertensive Agents/adverse effects , Benzopyrans/administration & dosage , Benzopyrans/adverse effects , Bisoprolol/administration & dosage , Bisoprolol/adverse effects , Blood Pressure/drug effects , Carbazoles/administration & dosage , Carbazoles/adverse effects , Carvedilol , Drug Monitoring , Erectile Dysfunction/chemically induced , Erectile Dysfunction/physiopathology , Erectile Dysfunction/prevention & control , Erectile Dysfunction/psychology , Ethanolamines/administration & dosage , Ethanolamines/adverse effects , Heart Rate/drug effects , Hemodynamics/drug effects , Humans , Hypertension/physiopathology , Male , Middle Aged , Nebivolol , Parasympathetic Nervous System/drug effects , Parasympathetic Nervous System/physiopathology , Penis/blood supply , Penis/innervation , Propanolamines/administration & dosage , Propanolamines/adverse effects , Treatment OutcomeABSTRACT
The aim of the work was to study effect of bisoprolol and nebivolol therapy on the sexual function of men with AH. 20 men aged 35-55 (48 +/- 3.5) yr with grade I and II AH received either drug for 2 months. Cardiac rhythm variability (CRV) was estimated in the end of the 4-week placebo period and after 2-month monotherapy. Dopplerography of penile arteries and a questionnaire study (as described by Vasilchenko) were conducted. Both drugs significantly increased the tone of the parasympathetic component of the vegetative nervous system, improved systolic blood flow in cavernous and dorsal arteries. The questionnaire study failed to revel significant changes of the sexual function. It is concluded that biosporolol and nebivolol did not compromise the sexual function of men with AH; they improve spectral CRV characteristics and blood flow in cavernous arteries.
Subject(s)
Benzopyrans/administration & dosage , Bisoprolol/administration & dosage , Blood Pressure/physiology , Circadian Rhythm , Ethanolamines/administration & dosage , Hypertension/drug therapy , Penile Erection/physiology , Sexuality/physiology , Adult , Antihypertensive Agents/administration & dosage , Blood Pressure/drug effects , Dose-Response Relationship, Drug , Electrocardiography , Humans , Hypertension/physiopathology , Male , Middle Aged , Nebivolol , Penile Erection/drug effects , Sexuality/drug effects , Surveys and QuestionnairesABSTRACT
Measurement of levels of hormones of the pituitary-gonadal system, dopplerography of penile arteries and questioning after Vasiltchenko were carried out in 30 men (age 35-55 years) with I-II degree arterial hypertension who received monotherapy with bisoprolol and nebivolol for 2 months. Treatment with both superselective beta-adrenoblockers was associated with significant lowering of systolic and diastolic blood pressure and heart rate. Antihypertensive effect of bisoprolol was significantly more pronounced than that of nebivolol. Bisoprolol and nebivolol significantly increased concentration of testosterone (by 82 and 85%, respectively) and prolactin (by 77 and 83%, respectively), lowered levels of estradiol and follicle-stimulating hormone, improved vascular blood flow in penile arteries, and did not worsen sexual function.
