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[Hexestrol inhibits ATP-induced contractile response of isolated preparations of pregnant human uterus].
Ziganshin, A U; Ablaeva, D N; Khasanov, A A; Ablaeva, S I; Nurullina, D V; Ziganshina, L E.
Eksp Klin Farmakol ; 71(6): 20-2, 2008.
Article in Russian | MEDLINE | ID: mdl-19140510

ABSTRACT

The results of in vitro experiments showed that hexestrol, a synthetic analog of estrogen hormones, at high concentrations inhibited the contractile response of isolated preparations of pregnant human uterus induced by ATP. It is suggested that estrogen hormones can interact with P2 receptors in human uterus during pregnancy.


Subject(s)
Adenosine Triphosphate/pharmacology , Estrogens, Non-Steroidal/pharmacology , Hexestrol/pharmacology , Myometrium/drug effects , Receptors, Purinergic P2 , Uterine Contraction/drug effects , Female , Humans , In Vitro Techniques , Myometrium/metabolism , Myometrium/physiology , Pregnancy , Purinergic P2 Receptor Agonists , Receptors, Purinergic P2/metabolism
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