1.
Boll Ist Sieroter Milan
; 61(1): 58-63, 1982 Mar.
Article
in Italian
| MEDLINE
| ID: mdl-7126330
ABSTRACT
The fixed combination (10 : 3) of amoxycillin and S-carboxymethylcysteine, which is indicated in the therapy of the respiratory tract infections, was given to rats by oral route to determine the blood levels and the concentrations in the pulmonary parenchyma and pleural exudate. In comparison with the antibiotic alone the combination determined higher levels of amoxycillin in the blood (0.5, 1.2 hours after administration) in the homogenized lung tissue (2 hours after administration) and in pleural inflammatory exudate (0.5, 1, 2 hours after administration) caused by intrapleural injection of carrageenan. The enhanced distribution of the antibiotic in the target tissues further supports the clinical usefulness of this combination.