1.
Farmaco
; 52(6-7): 421-8, 1997.
Article
in English
| MEDLINE
| ID: mdl-9372593
ABSTRACT
A number of benzyl and phenylethyl esters of indol-3-ylglyoxylic acid were synthesized and tested for their ability to displace [3H]Ro 15-1788 binding from bovine brain membranes. In these new compounds the oxygen atom of the ester function replaced the amide NH group of a class of previously described indolylglyoxylylamides, since it is reported in literature that in the beta-carboline series an ester function is more favourable to the activity than an amide group. However, none of the compounds showed an affinity at the Benzodiazepine receptor higher than that of the corresponding amides, demonstrating that the presence of the amide NH group is favourable to the interaction of ligands with the receptor site.
Subject(s)
Amides/chemistry , Esters/chemistry , Glyoxylates/chemistry , Indoles/chemistry , Receptors, GABA-A/metabolism , Amides/metabolism , Animals , Brain/metabolism , Cattle , Cell Membrane/metabolism , Esters/metabolism , GABA-A Receptor Antagonists , Glyoxylates/metabolism , In Vitro Techniques , Indoles/metabolism , Molecular Structure
2.
Farmaco
; 45(10): 1129-36, 1990 Oct.
Article
in English
| MEDLINE
| ID: mdl-2095156
3.
Farmaco Prat
; 42(12): 335-43, 1987 Dec.
Article
in Italian
| MEDLINE
| ID: mdl-3443172
4.
Farmaco Prat
; 41(1): 15-25, 1986 Jan.
Article
in Italian
| MEDLINE
| ID: mdl-3956712
5.
Boll Chim Farm
; 121(10): 535-44, 1982 Oct.
Article
in Italian
| MEDLINE
| ID: mdl-6219683
6.
Farmaco Prat
; 35(11): 544-52, 1980 Nov.
Article
in Italian
| MEDLINE
| ID: mdl-7461101
7.
Boll Chim Farm
; 114(1): 55-6, 1975 Jan.
Article
in Italian
| MEDLINE
| ID: mdl-1203100
8.
Farmaco Sci
; 28(7): 528-30, 1973 Jul.
Article
in Italian
| MEDLINE
| ID: mdl-4718400
9.
Farmaco Sci
; 28(5): 418-27, 1973 May.
Article
in Italian
| MEDLINE
| ID: mdl-4708082
10.
Farmaco Prat
; 27(7): 381-8, 1972 Jul.
Article
in Italian
| MEDLINE
| ID: mdl-5041969
11.
Farmaco Sci
; 27(3): 179-84, 1972 Mar.
Article
in Italian
| MEDLINE
| ID: mdl-4336683
12.
Farmaco Sci
; 26(11): 958-64, 1971 Nov.
Article
in Italian
| MEDLINE
| ID: mdl-4335244
Subject(s)
Halogens/analysis , Organophosphorus Compounds/analysis , Phosphorus/analysis , Cerium , Mercury , Microchemistry , Nitrates , Perchlorates
13.
Farmaco Sci
; 24(11): 930-7, 1969 Nov.
Article
in Italian
| MEDLINE
| ID: mdl-5361907
14.
J Pharm Sci
; 57(10): 1798-801, 1968 Oct.
Article
in English
| MEDLINE
| ID: mdl-5684761