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Bioorg Med Chem Lett ; 29(14): 1746-1748, 2019 07 15.
Article in English | MEDLINE | ID: mdl-31103445

ABSTRACT

Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhibition.


Subject(s)
Dual Specificity Phosphatase 1/antagonists & inhibitors , Humans , Structure-Activity Relationship
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