ABSTRACT
Braided stents are associated with a number of complications in vivo. Accurate computational modelling of these devices is essential for the design and development of the next generation of these stents. In this study, two commonly utilised methods of computationally modelling filament interaction in braided stents are investigated: the join method and the weave method. Three different braided stent designs are experimentally tested and computationally modelled in both radial and v-block configurations. The results of the study indicate that while both methods are capable of capturing braided stent performance to some degree, the weave method is much more robust.
Subject(s)
Computer Simulation , Models, Theoretical , Stents , Alloys/chemistry , Biomechanical Phenomena , Finite Element Analysis , Stress, MechanicalABSTRACT
Currently, there is no optimal treatment available for end stage tumour patients with airway stenosis. The PulmoStent concept aims on overcoming current hurdles in airway stenting by combining a nitinol stent with a nutrient-permeable membrane, which prevents tumour ingrowth. Respiratory epithelial cells can be seeded onto the cover to restore mucociliary clearance. In this study, a novel hand-braided dog bone stent was developed, covered with a polycarbonate urethane nonwoven and mechanically tested. Design and manufacturing of stent and cover were improved in an iterative process according to predefined requirements for permeability and mechanical properties and finally tested in a proof of concept animal study in sheep for up to 24 weeks. In each animal two stents were implanted, one of which was cell-seeded by endoscopic spraying in situ. We demonstrated the suitability of this membrane for our concept by glucose transport testing and in vitro culture of respiratory epithelial cells. In the animal study, no migration occurred in any of the twelve stents. There was only mild granulation tissue formation and tissue reaction; no severe mucus plugging was observed. Thus, the PulmoStent concept might be a step forward for palliative treatment of airway stenosis with a biohybrid stent device.
Subject(s)
Alloys , Blood Vessel Prosthesis , Endothelial Cells/metabolism , Stents , Tissue Engineering/methods , Animals , Cell Culture Techniques , Dogs , Female , SheepABSTRACT
The desire to reduce the strut thickness of cardiovascular stents has driven the development of a new high strength radiopaque alloy, based on additions of platinum to a chromium-rich iron based matrix. This paper reports on initial development of the alloy and the rationale for selection of the composition. Data is presented for tensile and microstructural characterization, surface oxide analysis, corrosion resistance and endothelial cell response of the alloy. The results demonstrate the solid solution strengthening effect of the platinum, with an average yield strength of 480 MPa achieved. The material surface consists of primarily chromium oxide which contributes to the high corrosion resistance observed. The cell assay result suggests that surfaces of this Pt-enhanced alloy endothelialize in a manner comparable to stainless steel.
Subject(s)
Alloys/chemistry , Cardiovascular System , Steel/chemistry , Stents , Alloys/analysis , Cell Proliferation , Corrosion , Endothelial Cells/cytology , Humans , Materials Testing , Oxygen/analysis , Photoelectron Spectroscopy , Surface Properties , Temperature , Tensile StrengthABSTRACT
The majority of stent materials are not fully compatible with magnetic resonance imaging due to their ferromagnetic or paramagnetic compositions. This leads to image artifact which can obscure clinical data in the vicinity of the stent. An Nb-28Ta-3.5W-1.3Zr alloy has been developed specifically to provide reduced magnetic susceptibility and therefore reduce image artifact. This study reports on initial surface characterization, corrosion behaviour, endothelial cell response and MR image performance. Surface analysis confirms the presence of a niobium oxide with some tantalum oxide also present. Electrochemical corrosion testing demonstrates the oxide to be stable with no evidence of film breakdown. Leaching of metallic ions during a 60-day immersion test shows low levels of release, comparable to cobalt-chromium L605. A short term endothelial cell adhesion study shows that the Nb-28Ta-3.5W-1.3Zr may be similar to stainless steel for supporting cell growth. The MR artifact assessment shows that the material has significantly reduced artifact compared to stainless steel. In summary, results from this initial study show that the Nb-28Ta-3.5W-1.3Zr meets many on the criteria expected of a stent material and that improved MR imaging behaviour is also obtained.
