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Bioorg Med Chem Lett
; 18(6): 2006-12, 2008 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-18313920
ABSTRACT
A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, mu opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective mu opioid receptor antagonist, which interacts selectively with mu peripheral receptors.