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1.
Neth J Med ; 75(5): 219, 2017 Jun.
Article in English | MEDLINE | ID: mdl-28653952
2.
Ir Med J ; 109(2): 361, 2016 Feb 19.
Article in English | MEDLINE | ID: mdl-27685694

ABSTRACT

Older adults are at increased risk of both central and peripheral neurological disorders. Impaired nerve and muscle deficits contribute to morbidity and reduced quality of life. Our aim was to define the utilization and yield of nerve conduction studies (NCS) and electromyography (EMG) in older adults. We reviewed NCS and EMG records for all patients older than age 65 in the year 2012. Of 1,530 NCS and EMGs performed, 352 (23%) were in patients older than 65 (mean age 73.7, 52% male). 288 (83.7%) of NCS were abnormal as were 102 (71.8%) of EMGs. The likelihood of having an abnormal test result increased with increasing age. The most common diagnosis was peripheral neuropathy 231 (65.4%). The incidence of peripheral neuropathy is particularly high in this age group and detection is vital to prevent morbidity and improve quality of life.

3.
BMJ Case Rep ; 20152015 Sep 08.
Article in English | MEDLINE | ID: mdl-26351312

ABSTRACT

A 30-year-old man attended the emergency department with a 4-day history of progressive, bilateral upper limb weakness. He had mild shortness of breath and occasional swallowing difficulties. One month prior to presentation, he had flu-like symptoms and diarrhoea. Examination revealed upper limb hypotonia, symmetrical distal arm weakness and hyporeflexia. Power and reflexes in the lower limbs were normal. Nerve conduction studies and lumbar puncture demonstrated features consistent with Guillain-Barré syndrome (GBS). The patient was treated with a 5-day course of intravenous immunoglobulins. He improved significantly over the next 2 weeks. Breathing and swallow function did not deteriorate and required no further intervention. He had a sustained improvement, and remained at baseline 1 year later. Work-up for underlying structural, infectious, inflammatory and paraneoplastic aetiologies were negative. Serum antiganglioside antibodies were positive for the anti-GT1a IgG isotype supporting the clinical diagnosis of the pharyngeal-cervical-brachial variant of GBS.


Subject(s)
Autoantibodies/blood , Guillain-Barre Syndrome/diagnosis , Immunoglobulins, Intravenous/therapeutic use , Gangliosides/immunology , Guillain-Barre Syndrome/immunology , Guillain-Barre Syndrome/physiopathology , Guillain-Barre Syndrome/rehabilitation , Humans , Male , Neurologic Examination , Occupational Therapy , Paresis/etiology , Speech Therapy , Spinal Puncture , Treatment Outcome
4.
Ir Med J ; 104(7): 202-4, 2011.
Article in English | MEDLINE | ID: mdl-21957686

ABSTRACT

The aim of this study was to retrospectively audit all electroencephalograms (EEGs) done over a 2-month period in 2009 by the Neurophysiology Department at Cork University Hospital. There were 316 EEGs performed in total, of which 176/316 (56%) were done within 24 hours of request. Out of 316 EEGs, 208 (66%) were considered 'appropriate' by SIGN and NICE guidelines; 79/208 (38%) had abnormal EEGs and 28 of these abnormal EEGs had epileptiform features. There were 108/316 (34%) 'inappropriate' requests for EEG; of these 15/108 (14%) were abnormal. Of the 67/316 (21%) patients who had EEGs requested based on a history of syncope/funny turns: none of these patients had epileptiform abnormalities on their EEGs. Our audit demonstrates that EEGs are inappropriately over-requested in our institution in particular for cases with reported 'funny turns' and syncope. The yield from EEGs in this cohort of patients was low as would be expected.


Subject(s)
Electroencephalography/statistics & numerical data , Practice Patterns, Physicians'/statistics & numerical data , Epilepsy/diagnosis , Female , Hospitals, University , Humans , Ireland , Male , Practice Guidelines as Topic , Retrospective Studies
5.
BMJ Case Rep ; 20112011 Mar 25.
Article in English | MEDLINE | ID: mdl-22700078

ABSTRACT

Arteriopathy is an uncommon complication of primary varicella zoster virus (VZV) infection in the immunocompetent adult. We report a case of a 39-year-old woman known to be VZV negative prior to the event. She presented to the emergency department having experienced an episode of expressive aphasia and right upper limb paraesthesia lasting 15 min. The symptoms followed a 3-day period of general malaise, arthralgia and a generalised maculopapular itchy rash involving face and limbs. No immunocompromise was detected but an infectious contact was identified in the home. Imaging findings were consistent with a focal cerebritis/vasculopathy and VZV infection was confirmed with cerebrospinal fluid PCR analysis. Resolution of radiological signs occurred following prompt treatment with appropriate antivirals.


Subject(s)
Cerebral Arterial Diseases/virology , Chickenpox/complications , Adult , Aphasia/etiology , Cerebral Arterial Diseases/cerebrospinal fluid , Cerebral Arterial Diseases/diagnosis , Chickenpox/cerebrospinal fluid , Chickenpox/diagnosis , Female , Humans , Magnetic Resonance Imaging , Paresthesia/etiology
7.
Ir Med J ; 102(7): 207-9, 2009.
Article in English | MEDLINE | ID: mdl-19771999

ABSTRACT

Alcohol consumption in Ireland has nearly doubled during the period 1989-2001. To evaluate the relationship of alcohol to fatal head injuries in the acute hospital setting we created a data base of all fatal traumatic brain injuries in the Department of Neuropathology at Beaumont Hospital over a ten year period (1997-2006 inclusive). 498 cases were identified (351 males: 147 females). Fatalities were highest in males aged 19-25 years (N=101) and 51-70 years (N=109). Falls (N=210) and road traffic accidents (N=183) were the commonest modes of presentation. 36/210 (17%) falls had positive blood alcohol testing, 9/210 (4.3%) had documentation of alcohol in notes but no testing, 35/210 (16.7%) tested negative for alcohol and 130/210 (61.9%) were not tested. The RTA group (N=183) comprised drivers (n=79), passengers (n=47) and pedestrians (n=57). 65/79 (82.2%) of drivers were males aged 19-25 years. Blood alcohol was only available in 27/79 (34.1%) drivers and was positive in 13/27 (48.1%). 14/75 (18.7%) pedestrians were tested for alcohol, 4/14 (28.6%) were positive. Overall 142/183 (77.6%) of the RTA group were not tested. The contribution of alcohol to fatal traumatic brain injuries is probably being underestimated due to omission of blood alcohol concentration testing on admission to hospital. Absence of national guidelines on blood alcohol testing in the emergency department compounds the problem.


Subject(s)
Accidental Falls/statistics & numerical data , Accidents, Traffic/statistics & numerical data , Alcohol Drinking/adverse effects , Brain Injuries/epidemiology , Brain Injuries/etiology , Emergency Service, Hospital/statistics & numerical data , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Autopsy , Brain Injuries/mortality , Databases, Factual , Ethanol/blood , Female , Humans , Ireland/epidemiology , Male , Middle Aged , Risk Assessment , Risk-Taking , Sex Factors , Young Adult
8.
Eur J Neurol ; 16(1): 148-53, 2009 Jan.
Article in English | MEDLINE | ID: mdl-19087159

ABSTRACT

BACKGROUND AND METHODS: We conducted an all-Ireland population-based prospective epidemiological survey of motor neurone disease (MND) using the Northern Ireland and Republic of Ireland MND registers to examine the incidence and prevalence of the disease over the period 2004-2005. RESULTS AND CONCLUSIONS: Incidence of MND was 1.9 per 100 000 person-years and rates were comparable in both the north and south of Ireland. Prevalence of MND was 5.0 per 100 000 population. When compared with previous published surveys of MND performed in the Republic of Ireland over the last 10 years, rates of disease have remained relatively constant. When standardized to the 1990 US population, the incidence of MND in Ireland was found to be consistent with other European prospective surveys of MND.


Subject(s)
Motor Neuron Disease/epidemiology , Registries/standards , Age Distribution , Age of Onset , Aged , Cohort Studies , Epidemiologic Methods , Europe/epidemiology , Female , Humans , Incidence , Ireland/epidemiology , Male , Middle Aged , Motor Neuron Disease/diagnosis , Prevalence , Prospective Studies , Reproducibility of Results , Sex Distribution
9.
J Neurol Neurosurg Psychiatry ; 79(1): 30-2, 2008 Jan.
Article in English | MEDLINE | ID: mdl-17634215

ABSTRACT

BACKGROUND: We conducted a prospective, population based study to examine trends in incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Ireland from 1995 to 2004. METHODS: The Irish ALS Register was used to identify Irish residents diagnosed with ALS between the 3 year period from 1 January 1995 to 31 December 1997 and the 3 year period from 1 January 2002 to 31 December 2004. RESULTS: 465 Irish residents were diagnosed with ALS during the study periods. The annual incidence rate of ALS in Ireland remained stable over this time (2.0 cases per 100,000 person-years; 95% CI 1.9, 2.2). Median survival of Irish ALS patients was 16.4 months and did not change during the study period. Demographics and clinical features of the incident and prevalent Irish ALS cohorts were markedly different.


Subject(s)
Amyotrophic Lateral Sclerosis/epidemiology , Amyotrophic Lateral Sclerosis/physiopathology , Aged , Aged, 80 and over , Demography , Female , Humans , Incidence , Ireland/epidemiology , Male , Population Surveillance , Prevalence , Prospective Studies
10.
J R Coll Gen Pract ; 38(307): 61-3, 1988 Feb.
Article in English | MEDLINE | ID: mdl-3204567

ABSTRACT

Of 164 young principal groups identified, 107 replied to a questionnaire asking for details of the groups and their activities. Eighty one per cent of the groups had been in existence for less than five years and 57% gave continuing medical education as one of the reasons for forming the group. The majority of groups were run informally and 55% had social meetings to which spouses were invited. The groups varied in size from six to 50 members and members' surgeries were the most popular meeting place. Clinical topics proved the most successful and group discussion was the preferred form of meeting. Groups formed for less than three years were less likely to have meetings with specialists than groups formed for three years or more and were more likely to have discussions about personal/partnership problems. Although 67% of the groups had sought outside help at some time 78% did not need any help at present.These self-help groups appear to be self-sufficient and to be meeting the continuing education and personal/social needs of young principals.


Subject(s)
Family Practice , Societies, Medical , Education, Medical, Continuing , Family Practice/education , Societies, Medical/organization & administration , United Kingdom
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