Subject(s)
Carcinoma, Squamous Cell/surgery , Lip Neoplasms/surgery , Mohs Surgery , Suture Techniques , Aged , Esthetics , Follow-Up Studies , Humans , Male , Wound Healing/physiologyABSTRACT
BACKGROUND: Numerous etiologic agents of subcutaneous phaeohyphomycosis have been reported. Colletotrichum spp, common plant pathogens, have been reported as a cause of ocular keratomycosis, but only one previous case of cutaneous disease (hyalohyphomycosis) has been attributed to this genus. OBJECTIVE: Our purpose was to describe 3 cases of subcutaneous phaeohyphomycosis due to Colletotrichum spp occurring in patients undergoing chemotherapy for hematologic malignancies. METHODS: Three cases of Colletotrichum-induced phaeohyphomycosis are reviewed. The clinical and histologic features of this infection are presented, the antifungal susceptibilities are reported, and treatment options are discussed. RESULTS: We describe the first report in which C coccodes and C gloeosporioides are implicated as etiologic agents of subcutaneous phaeohyphomycosis. Despite treatment, one patient died after the onset of visceral fungal disease. CONCLUSION: Colletotrichum spp may cause life-threatening phaeohyphomycosis in immunosuppressed patients. Prompt recognition and intervention with surgical and antifungal treatment may result in decreased morbidity and mortality associated with these infections.
Subject(s)
Colletotrichum/pathogenicity , Hematologic Neoplasms/complications , Mycoses/pathology , Adult , Antifungal Agents/therapeutic use , Fatal Outcome , Hematologic Neoplasms/microbiology , Humans , Immunocompromised Host , Male , Middle Aged , Morbidity , Mycoses/therapySubject(s)
AIDS-Related Opportunistic Infections/pathology , Acquired Immunodeficiency Syndrome/pathology , Dermatomycoses/pathology , Histoplasmosis/pathology , AIDS-Related Opportunistic Infections/drug therapy , Acquired Immunodeficiency Syndrome/complications , Acquired Immunodeficiency Syndrome/immunology , Adult , Amphotericin B/administration & dosage , Amphotericin B/therapeutic use , Antifungal Agents/administration & dosage , Antifungal Agents/therapeutic use , Dermatomycoses/drug therapy , Histoplasma/isolation & purification , Histoplasmosis/drug therapy , Humans , Immunocompromised Host , Injections, Intravenous , Itraconazole/therapeutic use , Male , RecurrenceABSTRACT
The d'embleé variant of mycosis fungoides initially described patients with a rapid onset of tumors without progression through patch- and plaque-stage disease. We report a case of a patient with the clinical presentation of mycosis fungoides d'embleé and correlate the histologic and immunophenotypic data with those of a more updated classification scheme.
Subject(s)
Lymphoma, Large B-Cell, Diffuse/pathology , Mycosis Fungoides/pathology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Disease Progression , Face/pathology , Humans , Ki-1 Antigen/analysis , Lymphoma, Large B-Cell, Diffuse/immunology , Lymphoma, Large B-Cell, Diffuse/therapy , Male , Middle Aged , Mycosis Fungoides/immunology , Mycosis Fungoides/therapy , Radiotherapy, Adjuvant , Treatment OutcomeABSTRACT
Recent cancer statistics estimate that the yearly incidence of cutaneous malignancies in the United States is similar to the incidence of all other cancers combined. Ultraviolet radiation-induced photodamage of the skin plays a large role in the growth of these skin cancers. The case of a 47-year-old white man with peculiar patterns of actinic skin damage on the anterior chest and back is presented, and the relationship of these findings with his choice of clothing is reviewed. The transmission of ultraviolet radiation through clothing fabrics is addressed, with recommendations for the use of clothing as an effective form of photoprotection.
