ABSTRACT
BACKGROUND: Gasoline is one of the most frequently utilized chemicals whose use is on the increase. Exposure to the volatile constituents of gasoline generates free radicals leading to oxidative stress. This is associated with nucleic acid, lipids, and protein damages leading to chronic diseases including cancers. Occupational exposure to this product is of public health concern, especially in the developing countries where the awareness and enforcement of safety measures are not adequate. MATERIALS AND METHODS: Plasma level of total antioxidant status (TAS) was compared between 90 roadside dispensers of gasoline and 90 age- and sex-matched controls. TAS was measured using standard colorimetric method. RESULTS: The mean age of the exposed and control groups is 29.03 ± 3.7 and 29.24 ± 3.5 years, respectively. The mean plasma TAS level of the exposed (0.60 ± 0.33 mmol/L) was significantly (P < 0.001) lower than that of the controls (1.29 ± 0.25 mmol/L). CONCLUSION: Our data have demonstrated higher level of oxidative stress in roadside dispensers of gasoline compared to the controls. This is an indication that roadside gasoline dispensers are probably at greater risk of developing chronic diseases associated with increased oxidative stress. Antioxidant supplementation may be of benefit to the roadside gasoline dispensers. Legislation on roadside gasoline dispensing should be enforced to reduce the incidence of long-term complications from repeated exposures.
