ABSTRACT
OBJECTIVES: To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device. METHODS: Forty-eight patients with MS and 46 healthy controls were included in a cross-sectional study. All participants underwent a complete functional evaluation of the visual pathway, which included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG). All tests were performed using the vision monitor unit Monpack One (Metrovision, France), a multifunction stimulator device. Retinal structural measurements were obtained in all subjects using Triton swept source optical coherence tomography (Topcon, Japan). RESULTS: Patients with MS presented reduced low-contrast VA (p < 0.001) and reduced CSV at medium (p=0.001, p=0.013) and low (p=0.001, p=0.002) spatial frequencies. All visual field parameters were found to be altered in MS patients compared with controls (≤0.001). Patients with MS presented lower amplitude of the P100 waveform of the mfVEP in areas corresponding to central (p < 0.001), inferonasal (p=0.001), and inferotemporal (p=0.003) retina. The pattern ERG did not show significant differences. Significant correlations were observed between structural retinal measurements and functional parameters, especially between the inner macular areas and measurements corresponding to contrast sensitivity and perimetry indexes. CONCLUSIONS: Patients with MS present visual dysfunction detectable with the vision monitor unit Monpack One. This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis.
ABSTRACT
La enfermedad de Parkinson (EP) es un proceso neurodegenerativo que afecta a unos 7,5 millones de personas en el mundo. Desde 2004, varios estudios han demostrado cambios en el espesor de diversas capas de la retina en la EP utilizando tomografía de coherencia óptica (OCT). Sin embargo, existen resultados contradictorios entre los diferentes estudios. Algunos de ellos relacionan los espesores retinianos con la severidad o duración de la enfermedad, lo cual convierte a las mediciones de la OCT en biomarcadores de progresión de la EP, inocuos y de fácil adquisición. También existen estudios que demuestran pérdida de capacidad o función visual desde fases tempranas de la enfermedad. Por último, los estudios más recientes que utilizan OCT de tecnología Swept Source demuestran aumento del espesor coroideo en la EP y aportan nueva información relacionada con el proceso degenerativo retiniano en esta enfermedad. Este trabajo pretende revisar la bibliografía existente sobre OCT y EP con el fin de determinar los parámetros retinianos y coroideos alterados en la EP y su posible utilidad clínica, así como analizar cuáles son las disfunciones visuales más relevantes en estos pacientes
Parkinson's disease (PD) is a neurodegenerative process that affects 7.5 million people around the world. Since 2004, several studies have demonstrated changes in various retinal layers in PD using optical coherence tomography (OCT). However, there are some discrepancies in the results of those studies. Some of them have correlated retinal thickness with the severity or duration of the disease, demonstrating that OCT measurements may be an innocuous and easy biomarker for PD progression. Other studies have demonstrated visual dysfunctions since early phases of the disease. Lastly, the most recent studies that use Swept Source OCT technology, have found choroidal thickness increase in PD patients and provide new information related to the retinal degenerative process in this disease. The aim of this paper is to review the literature on OCT and PD, in order to determine the altered retinal and choroidal parameters in PD and their possible clinical usefulness, and also the visual dysfunctions with higher impact in these patients
Subject(s)
Humans , Parkinson Disease/complications , Retinal Diseases/complications , Retinal Diseases/diagnosis , Biomarkers/analysis , Tomography, Optical Coherence/methods , Nerve Fibers/pathology , Parkinson Disease/physiopathologyABSTRACT
Parkinson's disease (PD) is a neurodegenerative process that affects 7.5 million people around the world. Since 2004, several studies have demonstrated changes in various retinal layers in PD using optical coherence tomography (OCT). However, there are some discrepancies in the results of those studies. Some of them have correlated retinal thickness with the severity or duration of the disease, demonstrating that OCT measurements may be an innocuous and easy biomarker for PD progression. Other studies have demonstrated visual dysfunctions since early phases of the disease. Lastly, the most recent studies that use Swept Source OCT technology, have found choroidal thickness increase in PD patients and provide new information related to the retinal degenerative process in this disease. The aim of this paper is to review the literature on OCT and PD, in order to determine the altered retinal and choroidal parameters in PD and their possible clinical usefulness, and also the visual dysfunctions with higher impact in these patients.
