Factores pronósticos de fracaso de la trabeculectomía en una población de Cuba / Prognostic factors for trabeculectomy failure in a Cuban population

OBJETIVO: Identificar los factores pronósticos de fracaso a medio plazo en la trabeculectomía. MÉTODO: Cohorte prospectiva en 113 ojos (113 pacientes) con glaucomas primarios de ángulo abierto o cerrado, pigmentario o juvenil que fueron intervenidos de trabeculectomía. Se definió fracaso si la presión intraocular mayor o igual de 18 mmHg con medicación (2 o más colirios), entre 1-4 años postoperatorios. Se calculó riesgo relativo y análisis de regresión logística. RESULTADOS: La trabeculectomía previa, la presión intraocular preoperatoria ≥ 31 mmHg, la raza negra y el daño glaucomatoso avanzado incrementaron el riesgo de fracaso en 7,9 veces (p = 0,036), 5,3 veces (p = 0,011) y 4,7 veces (p = 0,028 y p = 0,027), respectivamente. La presencia conjunta de 2 o más factores lo incrementó en 6,4 veces (p < 0,001). No se afectó por edad, sexo, colirios preoperatorios ni complicaciones quirúrgicas. CONCLUSIONES: La trabeculectomía previa, la presión intraocular preoperatoria ≥ 31 mmHg, la raza negra y el daño glaucomatoso avanzado son factores pronósticos de fracaso de la trabeculectomía, en orden decreciente de su asociación con el fracaso. La presencia conjunta de 2 o más factores incrementa el riesgo de fracaso. En estas situaciones se indica el uso de antimetabolitos transoperatorios

OBJECTIVE: To identify the prognostic factors for mid-term trabeculectomy failure. METHOD: A prospective cohort study was conducted on 113 eyes (113 patients) that had undergone a trabeculectomy for primary open or closed angle, pigmentary, or juvenile glaucoma. Surgical failure was defined if intraocular pressure was equal or more than 18 mmHg with medication (two or more drops), after 1-4 postoperative years. The relative risk was calculated and a logistic regression analysis was performed. RESULTS: Previous trabeculectomy, preoperative intraocular pressure ≥ 31 mmHg, black race, and advanced glaucoma increased the failure risk by 7.9 times (P=.036), 5.3 times (P=.011) and 4.7 times (P=.028, andP=.027), respectively. The addition of two or more factors increased the risk by 6.4 times (P<.001). It was not affected by age, sex, pre-operative drops, or surgical complication. CONCLUSIONS: Previous trabeculectomy, pre-operative intraocular pressure ≥ 31 mmHg, black race, and advanced glaucoma are prognostic factors for trabeculectomy failure, in decreasing order of their association with surgical failure. The addition of two or more factors increased the risk of failure. In those situations, the use of trans- operative anti-metabolites is suggested

Prognostic factors for trabeculectomy failure in a Cuban population.

OBJECTIVE: To identify the prognostic factors for mid-term trabeculectomy failure. METHOD: A prospective cohort study was conducted on 113 eyes (113 patients) that had undergone a trabeculectomy for primary open or closed angle, pigmentary, or juvenile glaucoma. Surgical failure was defined if intraocular pressure was equal or more than 18mmHg with medication (two or more drops), after 1-4 postoperative years. The relative risk was calculated and a logistic regression analysis was performed. RESULTS: Previous trabeculectomy, preoperative intraocular pressure ≥ 31mmHg, black race, and advanced glaucoma increased the failure risk by 7.9 times (P=.036), 5.3 times (P=.011) and 4.7 times (P=.028, and P=.027), respectively. The addition of two or more factors increased the risk by 6.4 times (P<.001). It was not affected by age, sex, pre-operative drops, or surgical complication. CONCLUSIONS: Previous trabeculectomy, pre-operative intraocular pressure ≥ 31mmHg, black race, and advanced glaucoma are prognostic factors for trabeculectomy failure, in decreasing order of their association with surgical failure. The addition of two or more factors increased the risk of failure. In those situations, the use of trans- operative anti-metabolites is suggested.