ABSTRACT
The obtained results on the study of the antimicrobial activity of lipid extracts of tissues of starfishes Linckia laevigata and Culcita novaeguineae and sea urchin Diadema setosum collected in the Nhatrang Bay (South China Sea) against nosocomial strains of Klebsiella pneumoniae, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, Candida sp., Streptococcus pyogenes, and Staphylococcus aureus are presented. The effect of the investigated extracts on Gram-positive, Gram-negative microorganisms, as well as yeast of the genus Candida, was determined. It was found that lipid extracts of echinoderms of the Nhatrang Bay exhibit the highest antimicrobial activity against the Gram-positive microorganisms, namely Streptococcus pyogenes.
Subject(s)
Anti-Infective Agents , Bays , Anti-Bacterial Agents/pharmacology , Anti-Infective Agents/pharmacology , Escherichia coli , Lipids , Microbial Sensitivity Tests , Plant Extracts/pharmacology , Staphylococcus aureusABSTRACT
The age dynamics of ovulatory function of rats which were kept in conditions of light deprivation and receiving luzindol (a blocker the melatonin receptors) is investigated in this research. Cytological research of an estrous cycle was conducted quarterly within two years. It is defined that the age changes of an ovulatory cycle in the mode of light deprivation came later and were less expressed in comparison with similar changes at control rat females kept in the conditions of standard lightning. In case of the blockade of melatonin receptors by luzindol, the dynamics of aging of reproductive system corresponded to the one in the control group kept in standard lightning mode.
Subject(s)
Darkness , Ovulation/physiology , Receptors, Melatonin/antagonists & inhibitors , Tryptamines/pharmacology , Animals , Estrous Cycle , Female , Lighting , RatsABSTRACT
In this paper, we investigated the dynamics of aging of the estrous function of female rats kept in the conditions of standard vivarium lighting and receiving luzindol - the blocker of melatonin receptors. Every three months, daily, for two weeks, vaginal smears were taken from the animals and cytological examination of the vaginal contents was conducted. Despite different mechanisms of the development of melatonin system failure (a decreased production of melatonin and a blockade of melatonin receptors), the effects of the influence on the ovulatory function are similar. In case of the blockade of melatonin receptors, the appearance of premature signs of aging of the reproductive function in rats was observed. It was manifested by an increased duration of ovulatory cycle; a decrease in the number of regular cycles; the emergence of irregular cycles; a decrease in the number of short estrous cycles and an increase of long cycles; the early development of persistent estrus.
