ABSTRACT
Complete blood count (CBC) parameters and lymphocyte-related ratios are found to be associated with inflammation and increased cytokine production. In Opioid Use Disorder (OUD), CBC parameters can be examined as the inflammatory (oxidative stress) biomarkers which could be used as an objective marker to support the OUD diagnosis and could be used as a disease severity marker. CBC parameters of 142 patients with OUD were examined. Lymphocytes, monocytes, basophiles, eosinophils and platelet counts (PLT), red blood cell levels (HGB), mean erythrocyte volume (MCV) and lymphocyte-related ratios were calculated. The control group consisted of 140 healthy individuals. WBC, neutrophil, lymphocyte, monocyte, platelet count, neutrophil, basophil percentage, neutrophil/ lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) values were significantly higher in OUD group. Lymphocyte, basophil percentage, basophile/lymphocyte ratio (BLR), red blood cell (RBC), hemoglobin were significantly higher in control group. Mean platelet volume (MPV), eosinophil/lymphocyte ratio (ELR), platelet/ lymphocyte ratio (PLR) values were not significant yet higher in the OUD group. CBC and related parameters (WBC, neutrophil, lymphocyte, monocyte, platelet count, neutrophil, basophil percentage, NLR, MLR) were found to be significantly higher in the OUD group. Evaluation of CBC parameters could be useful in treatment and follow-up of patients with OUD.
Subject(s)
Lymphocytes , Opioid-Related Disorders , Biomarkers , Blood Cell Count , Humans , Leukocyte Count , Neutrophils , Retrospective StudiesABSTRACT
OBJECTIVE: To identify the changes in QT dispersion (QTd), corrected QTd (QTcd), and P-wave dispersion (Pd) values with long-term alcohol abuse that could lead to severe ventricular arrhythmia, atrial fibrillation, and sudden death in alcohol use disorder (AUD) patients with excessive alcohol use. METHODS: This cross-sectional study included 48 individuals diagnosed with AUD based on DSM-5 criteria. Patients with a history of psychiatric diseases were not included. The control group comprised 48 individuals with no psychiatric diagnosis who did not abuse alcohol or other substances. Participants with body mass index > 24.9 kg/m² were excluded. Twelve-derivation electrocardiograms (ECG) were obtained from all participants. RESULTS: The mean ± SD age was 44.35 ± 10.24 years in the AUD group and 40.90 ± 13.45 years in the control group. There was no significant difference between the groups based on age (P = .108). There was a significant difference between the groups based on smoking status (P = .000). The mean ± SD period of alcohol use was 20.71 ± 12.04 years, and the alcohol intake was 5.88 ± 1.65 units/d. The AUD group demonstrated elevations in all ECG measures (QTd: 46.56 vs 26.67 ms, QTcd: 54.25 vs 30.88 ms, Pd: 44.69 vs 28.54 ms, all P = .000). CONCLUSIONS: AUD patients with excessive alcohol use had a higher risk of arrhythmia and sudden death compared to the control group. Consideration of ECG and referral to cardiologic examinations would contribute to the follow-up and health of patients with AUD.
