1.
ChemMedChem
; : e202400345, 2024 Jun 21.
Article
in English
| MEDLINE
| ID: mdl-39031732
ABSTRACT
Novel chalcogen-containing amides and esters bearing the benzenesulfonamide moiety have been synthesised upon nucleophilic conjugate addition of thiols and selenols to suitable electron-deficient alkenes. The activity of the synthesised compounds as Carbonic Anhydrases inhibitors has been investigated in vitro and the inhibition mechanism has been elucidated by X-rays studies.