Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 6 de 6
Filter
Add more filters










Database
Language
Publication year range
1.
J Endocrinol Invest ; 41(6): 703-709, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29230715

ABSTRACT

BACKGROUND: An impact of chronic lymphocytic thyroiditis (CLT) on papillary thyroid cancer (PTC) outcome has long been advocated but it is still controversial. PURPOSE: The aim of this study was to evaluate the prognostic value of CLT in a retrospective cohort of PTC patients and to characterize the lymphocytic subpopulations and infiltrate (LI). MATERIALS AND METHODS: We assessed 375 PTC patients, aged 45.2 ± 16.4 years, and treated with thyroidectomy and radioiodine remnant ablation, with a mean follow-up of 6.28 ± 3.86 years. In a subgroup of patients (n = 81) tissue sections were reviewed for the presence of CLT or lymphocytes associated with tumor in absence of background thyroiditis (TAL); cytotoxic CD8+/regulatory Foxp3+ T lymphocyte (CD8+/Foxp3+) ratio was characterized by immunohistochemistry: a low ratio is suggestive of a less effective anti tumor immune response. RESULTS: Seventy-five/375 patients (20%) had a histological diagnosis of CLT and showed at the last follow-up a significantly better outcome compared to those with no CLT (cure rate: 91.8 versus 76.3%, p = 0.003). LI was characterized in 81 PTC patients (24 with CLT and 57 with TAL): the peri-tumoral CD8+/Foxp3+ ratio was lower in patients not cured at the final evaluation. CONCLUSIONS: Our data suggest that concurrent CLT has a protective effect on PTC outcome and that the imbalance between cytotoxic and regulatory T lymphocytes in the peri-tumoral TAL may affect the tumor-specific immune response favoring a more aggressive behavior of cancer.


Subject(s)
Carcinoma, Papillary/immunology , Forkhead Transcription Factors/metabolism , Hashimoto Disease/immunology , T-Lymphocytes/immunology , Thyroid Neoplasms/immunology , Thyroidectomy , Adolescent , Adult , Aged , Aged, 80 and over , Carcinoma, Papillary/complications , Carcinoma, Papillary/surgery , Child , Child, Preschool , Female , Follow-Up Studies , Hashimoto Disease/complications , Hashimoto Disease/surgery , Humans , Male , Middle Aged , Prognosis , Retrospective Studies , Thyroid Neoplasms/complications , Thyroid Neoplasms/surgery , Young Adult
2.
Eur J Ophthalmol ; 18(6): 1031-3, 2008.
Article in English | MEDLINE | ID: mdl-18988185

ABSTRACT

PURPOSE: A case of orbital infiltration by breast carcinoma in a male patient causing mild enophthalmos and subcutaneous mass detected accidentally during peribulbar anesthesia for cataract surgery is discussed. METHODS: The authors report a case of a 65-year-old man who came to the Ophthalmology Department for cataract surgery. During the presurgery peribulbar injection, a hard palpable mass located under the inferior left eyelid was noted, together with mild enophthalmos. A historical clinical screening revealed that 5 years previously the patient had undergone a right radical mastectomy to treat a ductal carcinoma of the breast. RESULTS: The patient underwent an incisional biopsy of the orbital mass that confirmed the clinical hypothesis of a metastasis. DISCUSSION: This case highlights the importance of the collection and screening of detailed clinical information on the patient before every ophthalmic operation including cataract surgery. The occurrence of progressive enophthalmos can represent an unusual symptom of orbital metastasis, commonly presenting with proptosis and diplopia.


Subject(s)
Anesthesia, Local , Breast Neoplasms, Male/pathology , Carcinoma, Ductal, Breast/secondary , Cataract Extraction , Orbital Neoplasms/secondary , Aged , Biopsy , Carcinoma, Ductal, Breast/diagnosis , Carcinoma, Ductal, Breast/radiotherapy , Enophthalmos/diagnosis , Enophthalmos/etiology , Fatal Outcome , Humans , Magnetic Resonance Imaging , Male , Orbital Neoplasms/diagnosis , Orbital Neoplasms/radiotherapy
3.
J Endocrinol Invest ; 29(4): 337-41, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16699300

ABSTRACT

The present study investigated whether trophoblast, decidua and fetal membranes express nerve growth factor (NGF) mRNA and peptide. Tissue specimens were collected in the first and third trimester of pregnancy from women undergoing voluntary pregnancy interruption (no.= 6; from 8 to 12 gestational weeks) and from women having an elective caesarean section at term (no.= 6; week 39-40 of pregnancy). Using reverse transcriptase-polymerase chain reaction (RT-PCR), trophoblast, amnion/chorion and maternal decidua showed the expression of NGF mRNA both in early gestation and at term. By immunohistochemistry, the immunoreactive NGF was found in the cyto and syncytial trophoblast cells, chorionic mesodermic cells and in decidua. Vessel endothelial cells were stained in maternal compartments, while fetal vessels were unstained. These results, showing the expression and localization of NGF, support the current concept that human placenta is a potent neuroendocrine organ throughout gestation.


Subject(s)
Decidua/metabolism , Extraembryonic Membranes/metabolism , Nerve Growth Factor/biosynthesis , Nerve Growth Factor/genetics , RNA, Messenger/metabolism , Trophoblasts/metabolism , Female , Humans , Pregnancy , Pregnancy Trimester, First/physiology , Pregnancy Trimester, Third/physiology , Reverse Transcriptase Polymerase Chain Reaction
4.
Histol Histopathol ; 20(4): 1115-20, 2005 10.
Article in English | MEDLINE | ID: mdl-16136494

ABSTRACT

Human adrenocortical cells have been shown to express cytokeratins and vimentin. Nestin is an intermediate filament protein that is mainly expressed in the developing nervous system and that has been recently reported in rat adrenal gland as well. Using immunohistochemical and biochemical approaches, the present study demonstrates that nestin is constantly expressed in situ in the cortex of normal human adrenal glands. Nestin expressing cells were prevalently located in the zona reticularis but some positive cells could be spotted in the zona fasciculata as well. Moreover, patches of nestin-positive cells have been constantly detected on sections of cortical adenomas. In contrast, adrenal carcinomas displayed a variable number of nestin-immunoreactive cells that in some cases were virtually absent. Samples of renal clear cell carcinoma metastasis in the adrenals were also examined which did not show nestin-immunoreactivity. We propose that a positive nestin-immunoreaction could be useful in differential diagnosis of clear cell tumors in adrenal glands.


Subject(s)
Adrenal Cortex Neoplasms/metabolism , Adrenal Glands/metabolism , Adrenal Glands/pathology , Intermediate Filament Proteins/biosynthesis , Nerve Tissue Proteins/biosynthesis , Adenocarcinoma, Clear Cell/metabolism , Adenocarcinoma, Clear Cell/pathology , Adrenal Cortex Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Blotting, Western , Case-Control Studies , Electrophoresis, Polyacrylamide Gel , Female , Humans , Intermediate Filament Proteins/genetics , Male , Middle Aged , Nerve Tissue Proteins/genetics , Nestin , Retrospective Studies
6.
Dig Liver Dis ; 37(1): 65-7, 2005 Jan.
Article in English | MEDLINE | ID: mdl-15702863

ABSTRACT

The popularity in Western countries of dishes based on raw fish has led to an increased incidence of anisakiasis, a human parasitic disease caused by the ingestion of live anisakid larvae. The entire digestive tract may be involved, but the stomach and the small intestine are the most frequently affected sites. We report a case of acute abdomen due to Anisakis simplex infection that caused small bowel obstruction.


Subject(s)
Abdomen, Acute/parasitology , Anisakiasis/diagnosis , Intestinal Obstruction/parasitology , Acute Disease , Adult , Animals , Anisakiasis/complications , Anisakiasis/surgery , Fishes/parasitology , Food Parasitology , Humans , Jejunum/parasitology , Jejunum/surgery , Male
SELECTION OF CITATIONS
SEARCH DETAIL
...