ABSTRACT
We recently experienced an 87-yr-old man with gastric yolk sac tumor. Preoperative diagnosis was poorly differentiated adenocarcinoma in the cardia of stomach without apparent metastasis. A total gastrectomy was performed. The precise histological examination after surgery revealed the tumor was composed of pure gastric yolk sac tumor without adenocarcinomatous components. The surgical margin and the resected lymph nodes were histologically negative for the tumor and a curative resection was performed. Five months after the operation, enlargement of the intraabdominal lymph nodes occurred with elevation of serum alpha fetoprotein (AFP), and the patient died 2 mo later. Gastric yolk sac tumors are very rare, and only six cases of gastric yolk sac tumors have been previously reported in the literature. Five out of six cases are accompanied by components of adenocarcinoma, and our present case is the second report of pure gastric yolk sac tumor to the best of our knowledge.
Subject(s)
Adenocarcinoma/surgery , Endodermal Sinus Tumor/pathology , Endodermal Sinus Tumor/surgery , Stomach Neoplasms/pathology , Stomach Neoplasms/surgery , Adenocarcinoma/pathology , Aged , Aged, 80 and over , Fatal Outcome , Gastrectomy , Humans , Lymphatic Metastasis , MaleABSTRACT
We report a case of advanced schirrous gastric cancer with carcinomatous peritonitis. Chemotherapy with TS-1 was applied during the first 4 weeks, but the tumor did not respond to this therapy. Next, paclitaxel (TXL) was administered at a weekly dose of 90 mg/body/day for 3 weeks followed by a week interval of rest. Remarkable mass reduction of primary tumor was observed after 3 courses of treatment, and the symptom derived from primary tumor was relieved without significant side effects. The clinical course for schirrous gastric cancer with carcinomatous peritonitis is still miserable for patients, although many attempts have been made to improve its prognosis. A weekly paclitaxel regimen appears to be one of the promising treatment for schirrous gastric cancer.
Subject(s)
Adenocarcinoma, Scirrhous/drug therapy , Antineoplastic Agents, Phytogenic/administration & dosage , Paclitaxel/administration & dosage , Peritonitis/drug therapy , Stomach Neoplasms/drug therapy , Adenocarcinoma, Scirrhous/secondary , Aged , Drug Administration Schedule , Humans , Male , Peritoneal Neoplasms/secondary , Peritonitis/etiology , Stomach Neoplasms/pathologyABSTRACT
A 22-year-old woman was admitted to this institution because of severe liver dysfunction that looked like acute hepatitis. Abdominal ultrasonography revealed a liver mass 20 mm in diameter that resembled the bull's-eye sign. Enhanced CT revealed a low-density mass. The mass was hypointense in T1-weighted MRI images and slightly hyperintense in T2-weighted MRI images. Needle biopsy of the liver under ultrasound guidance led to a diagnosis of solitary necrotic nodule of the liver. The tumor consisted of coagulation necrosis surrounded by fibrotic tissue. These pathologic features were consistent with the Imaging findings.
