ABSTRACT
This study is concerned with variations in the oestrous cycle of the Sprague-Dawley rat following the intraperitoneal administration of maize oil solutions of Cannabis sativa resin and smoke condensate in doses of 10 and 20 mg/kg. Oestrus was shortened with doses of both the resin and the smoke condensate, whereas dioestrus was lengthened with the 20 mg/kg smoke condensate. ALso observed was a lengthening of postoestrus following the administration of 20 mg/kg of either the resin or the smoke condensate.
Subject(s)
Cannabinoids/pharmacology , Cannabis , Estrus/drug effects , Animals , Cannabinoids/administration & dosage , Diestrus/drug effects , Dose-Response Relationship, Drug , Female , Pregnancy , Proestrus/drug effects , Rats , Rats, Inbred Strains , Resins, Plant/administration & dosage , Resins, Plant/pharmacology , Smoke , Time FactorsABSTRACT
Research work on the possible mutagenic effects of the amphetamine, sympathomimetic amine, was carried out on the rat. The method used was the dominant lethal assay, in its sub-acute form. Dextroamphetamine sulphate was administered orally. At the dosage and frequency of the test, dextroamphetamine sulphate was found to be a significantly mutogenic agent. The over-all mutagenic index was 13.92% (P less than 0.01) for the test group and 8.90% for the control group.
