1.
Bioorg Med Chem Lett
; 13(23): 4193-6, 2003 Dec 01.
Article
in English
| MEDLINE
| ID: mdl-14622999
ABSTRACT
Replacement of the morpholine C-ring of linezolid 1 with a 1,3,4-thiadiazolyl ring leads to oxazolidinone analogues 5 having potent antibacterial activity against both gram-positive and gram-negative organisms. Conversion of the C5 acetamide group to a thioacetamide further increases the potency of these compounds.