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FEBS Open Bio ; 10(2): 259-267, 2020 02.
Article in English | MEDLINE | ID: mdl-31898867

ABSTRACT

Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown. Here, we performed in silico analysis to investigate signaling alterations in cardiomyocytes induced by inhalational [sevoflurane (Sevo)] and intravenous [propofol (Prop)] anesthetics. Bioinformatics analysis revealed that nuclear factor-kappa B (NF-kB) signaling was inhibited by Sevo and promoted by Prop. Moreover, nuclear accumulation of p65 and transcription of NF-kB-regulated genes were suppressed in Sevo-administered mice, suggesting that Sevo inhibits the NF-kB signaling pathway. Our data demonstrate that NF-kB signaling is inhibited by Sevo and promoted by Prop. As NF-kB signaling plays an important role in myocardial remodeling, our results suggest that anesthetics may affect myocardial remodeling through NF-kB.


Subject(s)
Myocardium/metabolism , Myocytes, Cardiac/metabolism , NF-kappa B/metabolism , Aged , Anesthetics, Intravenous/pharmacology , Animals , Atrial Remodeling/drug effects , Heart/drug effects , Heart/physiology , Humans , Male , Mice , Middle Aged , Myocytes, Cardiac/drug effects , NF-kappa B/drug effects , Propofol/pharmacology , Sevoflurane/pharmacology , Signal Transduction/drug effects , Ventricular Remodeling/drug effects
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