ABSTRACT
OBJECTIVE: Non-Hodgkins lymphomas (NHL) rarely affect the vagina. As a result, a standard treatment has not been defined. CASE REPORT: A 34-year-old female virgin patient with a primary vaginal NHL stage IEA, diffuse large cell B lineage, showed an excellent response to cytotoxic chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone) without surgery or radiotherapy. She had experienced no recurrence after 40 months. CONCLUSION: In young patients who wish to preserve their fertility, chemotherapy alone may be the treatment of choice for primary diffuse large B-cell NHL of the lower female genital tract.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/pathology , Vaginal Neoplasms/drug therapy , Vaginal Neoplasms/pathology , Adult , Biopsy, Needle , Cyclophosphamide/therapeutic use , Doxorubicin/administration & dosage , Female , Follow-Up Studies , Humans , Immunohistochemistry , Lymphoma, Large B-Cell, Diffuse/diagnostic imaging , Prednisone/administration & dosage , Treatment Outcome , Ultrasonography , Vaginal Neoplasms/diagnostic imaging , Vincristine/administration & dosageABSTRACT
Neuroendocrine carcinomas primitive neuroectodermal tumor (PNET) arise from Kulchitsky cells and are frequently seen in gastrointestinal tract and lungs. But they are unusual in gynecology practice. We presented a case of PNET arising in the uterine corpus of a 22-year-old woman. To our knowledge, this is the first description of small-cell carcinoma of the uterine corpus with a pseudocyst formation within the myometrium without endometrial invasion.