Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 7 de 7
Filter
2.
J Oncol Pharm Pract ; 26(8): 2052-2057, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32299316

ABSTRACT

INTRODUCTION: Everolimus is a mammalian target of rapamycin inhibitor and is approved as second-line treatment or beyond for renal cell carcinoma. We report a case of a 75-year-old male treated with everolimus for metastatic renal cell carcinoma, after sunitinib treatment, who was diagnosed with human herpesvirus 6 encephalitis. CASE REPORT: After 39 months of everolimus, 10 mg per day, our patient was admitted with fever, consciousness disorders and a partial epileptic crisis. Laboratory tests revealed lymphopenia (170 lymphocytes/mm3), and polymerase chain reaction in cerebrospinal fluid was positive for human herpesvirus 6. Brain magnetic resonance imaging study demonstrated hippocampal abnormality and a pontine lesion. MANAGEMENT AND OUTCOME: The patient stopped everolimus treatment indefinitely. He received ganciclovir initially intravenously, with a rapid clinical improvement, as well as polyvalent immunoglobulins were given to correct hypogammaglobulinemia. Two months later, antiviral therapy was switched to oral ganciclovir, which was never stopped. A new lumbar puncture was performed one month after the initiation of antiviral treatment, which did not reveal human herpesvirus 6 DNA anymore. DISCUSSION: Human herpesvirus 6 encephalitis is more common in hematopoietic stem cell transplant recipients and HIV patients. This is the first case probably associated to everolimus treatment. In contrast to most patients diagnosed with this infection, who either die or develop neurologic sequelae, our patient almost fully recovered two months later.


Subject(s)
Carcinoma, Renal Cell/drug therapy , Encephalitis, Viral/chemically induced , Everolimus/adverse effects , Kidney Neoplasms/drug therapy , Roseolovirus Infections/chemically induced , Aged , Antiviral Agents/therapeutic use , Encephalitis, Viral/drug therapy , Humans , Male , Roseolovirus Infections/drug therapy
4.
Sci Rep ; 9(1): 19185, 2019 12 16.
Article in English | MEDLINE | ID: mdl-31844135

ABSTRACT

Breast background parenchymal enhancement (BPE) is an increasingly studied MRI parameter that reflects the microvasculature of normal breast tissue, which has been shown to change during neoadjuvant chemotherapy (NAC) for breast cancer. We aimed at evaluating the BPE in patients undergoing NAC and its prognostic value to predict recurrence. MRI BPE was visually and quantitatively evaluated before and after NAC in a retrospective cohort of 102 women with unilateral biopsy-proven invasive breast cancer. Pre-therapeutic BPE was not predictive of pathological response or recurrence. Quantitative post-therapeutic BPE was significantly decreased compared to pre-therapeutic value. Post-therapeutic quantitative BPE significantly predicted recurrence (HR = 6.38 (0.71, 12.06), p < 0.05).


Subject(s)
Breast Neoplasms/pathology , Breast Neoplasms/therapy , Magnetic Resonance Imaging , Neoadjuvant Therapy , Neoplasm Recurrence, Local/pathology , Breast/diagnostic imaging , Breast/pathology , Breast Neoplasms/diagnostic imaging , Disease-Free Survival , Female , Follow-Up Studies , Humans , Middle Aged , Multivariate Analysis , Neoplasm Recurrence, Local/diagnostic imaging , Proportional Hazards Models
6.
Rev Prat ; 66(5): e216, 2016 May.
Article in French | MEDLINE | ID: mdl-30512593
7.
Rev Prat ; 66(5): e217-e223, 2016 May.
Article in French | MEDLINE | ID: mdl-30512594
SELECTION OF CITATIONS
SEARCH DETAIL
...