ABSTRACT
Ultrastructural and immunocytochemical results of studies on interneuronal relationship in vegetative ganglia were represented. Age-related changes of synapses (appearance of synaptic type vesicles and smooth endoplasmic reticulum cisterns in postsynaptic terminals), peculiarities of interneuronal links in neurons containing neuropeptide Y and NO-synthase and structural manifestations of non-synaptic interneuronal links were shown. Modern views on interneuronal communications were discussed.
Subject(s)
Ganglia, Autonomic/ultrastructure , Interneurons/ultrastructure , Aging/metabolism , Animals , Dogs , Ganglia, Autonomic/metabolism , Immunohistochemistry , Interneurons/metabolism , Male , Microscopy, Electron , Neuropeptide Y/metabolism , Nitric Oxide Synthase/metabolism , Rats , Rats, Inbred SHR , Rats, Sprague-Dawley , Rats, WistarABSTRACT
Immunohistochemical investigation of NO-synthase in brain astrocytic tumors revealed intense reaction in many tumor cells as well as direct correlation in the intensity of reaction and the degree of tumor anaplasia. Grade I astrocytomas did not show immunoreactivity in contrast to high anaplastic tumors where many cells had positive reaction with a different degree of intensity. Positive immunoreaction was shown in many giant cells. Small cell glioblastomas and oligodendrogliomas were immunonegative. There was a direct correlation between NO-synthase expression and glial fibrillar acidic protein.