ABSTRACT
Intensification of lipid peroxidation against the background of exhaustion of the antioxidant protective system was demonstrated in 70 rats with experimental bile peritonitis. Free radical oxidation primarily concerned free lipids and fatty acids in the plasma and to a lesser extent erythrocyte membrane lipids.
Subject(s)
Antioxidants/metabolism , Bile , Lipid Peroxidation , Peritonitis/blood , Animals , Bile/chemistry , Catalase/analysis , Ceruloplasmin/analysis , Erythrocytes/enzymology , Male , Malondialdehyde/blood , Models, Animal , Peritonitis/chemically induced , Peroxidase/blood , RatsABSTRACT
Combined postoperation treatment with sodium hypochlorite and alpha-tocopherol broke the chain of free radical reactions in lipids and promoted normalization of LPO processes in the plasma and erythrocytes of 250 rats with experimental bile peritonitis.
Subject(s)
Antioxidants/metabolism , Bile , Peritonitis/blood , Reactive Oxygen Species/metabolism , Sodium Hypochlorite/administration & dosage , alpha-Tocopherol/administration & dosage , Animals , Lipid Peroxidation , Male , RatsABSTRACT
The composition of contractile and regulatory proteins was studied in rat muscles with different functions. The rats were exposed to weightlessness for 18.5 days during a space journey in biosatellite Cosmos-1129. Under the effect of weightlessness the myosin light chain composition changed, the quantity of myosin LC-3 subunits increased in the soleus and extensor digitorum longus (EDL) while it decreased in the triceps and brachialis muscles. The experiments showed changes in the subunit composition of the TN-TM complex, too. The results obtained are in favour of a possible adequate transformation of fibril phenotypes of some (antigravitational) muscles under the effect of spaceflight.
